Dormin Tablet
Nitrazepam
10mg
Micro Labs Ltd.
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| Retail Price | 3.05 NPR |
Indications
Dormin Tablet is used for:
Insomnia
Adult Dose
Oral
Short-term management of insomnia
Adult: 5 mg at night; increase to 10 mg if necessary.
Elderly: and debilitated patients: ?normal adult dose.
Child Dose
Oral
Infantile spasms
Child: Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Myasthenia gravis, narrow-angle glaucoma, severe respiratory insufficiency, sleep apnoea syndrome, severe hepatic impairment, porphyria.
Precautions
May induce anterograde amnesia; caution patients to have uninterrupted sleep of 7-8 hr after ingestion of dose. May impair ability to drive or operate machinery. Depression, especially if suicidal risk may be present. History of drug abuse or acute alcoholism. Hepatic and renal impairment. Respiratory disease. Debilitated patients. Patients who are at risk of falls. Children, elderly. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives. Effects may be antagonised by theophylline. Increased levels/effects with probenecid. Reduced levels/effects with rifampicin. May reduce effects of levodopa.
Adverse Effects
Side effects of Nitrazepam :
Hypotension, palpitation; agitation, aggressiveness, amnesia, ataxia, confusion, delusions, disorientation, dizziness, fatigue, hallucination, hangover, headache, irritability, nightmares, psychoses, rage, restlessness, sedation; rash; changes in libido; constipation, diarrhoea, excessive salivation, heartburn, nausea, vomiting; granulocytopenia, leukopenia; falling, muscle weakness; blurred or double vision; tinnitus (associated with withdrawal); aspiration, increased bronchial secretion, dyspnoea.
Mechanism of Action
Nitrazepam is a benzodiazepine with a pronounced sleep-inducing activity. It depresses the reticular-activating system in the brainstem by enhancing the inhibitory effect of GABA on brain cells, thus preventing excessive brain activity.
Note
Dormin 10mg Tablet manufactured by Micro Labs Ltd.. Its generic name is Nitrazepam. Dormin is availble in Nepal.
Farmaco Nepal drug index information on Dormin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.