Dorzox T Eye Drop
Dorzolamide 2% + Timolol 0.5% Eye prep
0.5%w/v + 2%w/v
Cipla Ltd.
| Pack size | 5ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 400.01 NPR |
Indications
Dorzox T Eye Drop is used for:
Open-angle glaucoma, Ocular hypertension
Adult Dose
Ophthalmic
Ocular hypertension; Open-angle glaucoma
Adult: Instill 1 drop to the affected eye bid.
Child Dose
Ophthalmic
Ocular hypertension; Open-angle glaucoma
<2 years
Contraindicated
>2 years
Instill 1 drop to the affected eye bid.
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 Not recommended.
Administration
Contra Indications
Hypersensitivity to any of the components or sulphonamide. History or current bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, CrClr <30 ml/min and hyperchloraemic acidosis.
Precautions
Hepatic impairment, mild to moderate renal impairment, children <2 yr. Avoid use in pregnancy and lactation. Prinzmetal's angina, cardiac disease, hypotension, myasthenia gravis, history of renal calculi, history of intra-ocular surgery, pre-existing chronic corneal defects. May worsen severe peripheral and central circulatory disorders. May mask symptoms of hypoglycaemia and hyperthyroidism. Withdraw gradually, especially in patients with coronary heart disease. Discontinue treatment at the first signs or symptoms of cardiac failure. Contact lenses to be removed before eyedrop application and wait at least 15 minutes before reinsertion. Apply other eyedrops 10 minutes apart. May affect ability to drive or operate machinery as it may cause blurred vision.
Lactation: Excreted in breast milk; not recommended
Pregnancy-Lactation
Interactions
Additive hypotension and bradycardia with oral calcium channel blockers, catecholamine-depleting drugs or beta-blockers, antiarrhythmics (e.g. amiodarone), digitalis glycosides, parasympathomimetics, narcotics and MAOIs. Additive systemic side effects with oral carbonic anhydrase or beta-blockers; avoid concurrent use. Additive systemic beta-blockade with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol.
Adverse Effects
Side effects of Dorzolamide 2% + Timolol 0.5% Eye prep :
>10%
Dorzolamide
Ocular burning, stinging, discomfort (33%),Bitter taste (25%),Superficial punctate keratitis (10-15%),Ocular allergic reactions (10%)
Frequency Not Defined
Dorzolamide,Blurred vision,Ocular dryness,Photophobia,Ocular redness,Tearing,Stevens-Johnson syndrome,Toxic epidermal necrolysis
Timolol
Arrythmia,Bradycardia,Syncope,Fatigue,Headache,Dyspnea,Bronchospasm,Chest pain,Edema,Paresthesia,Nausea,Rales,Depression,Decreased exercise tolerance,Raynaud's phenomenon
Potentially Fatal: Cardiac failure, bronchospasm.
Mechanism of Action
Timolol maleate, a nonselective beta-adrenergic blocker, reduces aqueous humor formation. Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide.
By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.
Note
Dorzox T 0.5%w/v + 2%w/v Eye Drop manufactured by Cipla Ltd.. Its generic name is Dorzolamide 2% + Timolol 0.5% Eye prep. Dorzox T is availble in Nepal.
Farmaco Nepal drug index information on Dorzox T Eye Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.