Dotav 40 Tablet
Drotaverine Hydrochloride
40mg
Lomus Pharmaceutical Pvt. Ltd.
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Available as:
Indications
Dotav 40 Tablet is used for:
Gastrointestinal tract spasm, Irritable bowel syndrome, Dysmenorrhea, Biliary colics, Renal colics
Adult Dose
Oral
As an antispasmodic
Adult: 1 to 2 tablets, 3 times daily.
Injection: Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily.
For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.
Child Dose
Oral
As an antispasmodic
Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
40 mg 1-2 times daily
Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
20 mg 1-2 times daily
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Severe renal/hepatic/cardiac dysfunction. Porphyria.
Precautions
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
Pregnancy-Lactation
Interactions
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
Adverse Effects
Side effects of Drotaverine Hydrochloride :
Vertigo, nausea, vomiting, dry mouth.
Mechanism of Action
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
Note
Dotav 40 40mg Tablet manufactured by Lomus Pharmaceutical Pvt. Ltd.. Its generic name is Drotaverine Hydrochloride. Dotav 40 is availble in Nepal.
Farmaco Nepal drug index information on Dotav 40 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.