Dothip Tablet
Dothiepin (Dosulepin)
75mg
Micro Labs Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 8.50 NPR |
Available as:
Indications
Dothip Tablet is used for:
Depression
Adult Dose
Oral
Depression
Adult: Initially, 75 mg daily as a single or in divided doses at night, may increase to 150 mg daily. In severe cases, may increase up to 225 mg daily.
Elderly: Initially, 50-75 mg daily in divided doses. Maintenance: Half the normal adult dose.
Hepatic impairment: Contraindicated.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Manic phase of bipolar disorder, arrhythmias, heart block, immediate recovery period after MI. Hepatic impairment. Concomitant admin w/ MAOIs or w/in 14 days after discontinuation.
Precautions
Patient w/ history of bipolar disorder and psychosis. Patient w/ severe CV disease including heart failure, conduction disorders or cardiac arrhythmia; risk factors for QTc prolongation/TdP including congenital long QT syndrome; significant risk of suicide; glaucoma, urinary retention, prostatic hypertrophy. Avoid abrupt withdrawal. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, if affected do not drive or operate machinery. Monitoring Parameters Closely monitor for clinical worsening and suicidality (esp at the beginning of the treatment and dose change). Perform ECG prior to treatment. Monitor CV and ECG. Examine eyes regularly during prolonged treatment.
Pregnancy-Lactation
Interactions
Increased risk of ventricular arrhythmias w/ drugs that prolong QT interval. May potentiate sedative effect w/ barbiturates, tranquilisers, CNS depressants. May block antihypertensive effect of guanethidine and other adrenergic neurone blocking drugs. May potentiate effects of anticholinergics, antihistamines, sympathomimetics. Increased risk of postural hypotension w/ diuretics. May antagonise effect of antiepileptics.
Potentially Fatal: Concomitant admin w/ MAOIs or w/in 14 days after discontinuation may cause cerebral excitation followed by coma or dangerous hyperthermia.
Adverse Effects
Side effects of Dothiepin (Dosulepin) :
Drowsiness, dizziness, tremor, confusional states, paraesthesia, EEG patterns alterations, disorientation; dry mouth, urinary retention, sweating; hypotension, postural hypotension, tachycardia, arrhythmias (including ventricular tachycardia, ventricular fibrillation and torsades de pointes), conduction defects, palpitations; increased or decreased libido; constipation, nausea, vomiting; blurred vision. Rarely, dysarthria, extrapyramidal symptoms, paralytic ileus, tremor, neuroleptic malignant syndrome, precipitation of angle-closure glaucoma.
Mechanism of Action
Dosulepin hydrochloride (also known as dothiepin) is a TCA which inhibits norepinephrine and 5-hydroxytryptamine uptake from the nerve endings, thereby increases availability at central norepinephrine synapses. It has anticholinergic, antihistamine and central sedative properties.
Note
Dothip 75mg Tablet manufactured by Micro Labs Ltd.. Its generic name is Dothiepin (Dosulepin). Dothip is availble in Nepal.
Farmaco Nepal drug index information on Dothip Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.