Doxin Capsule

Doxepin
25mg
Intas Pharmaceuticals Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 9.04 NPR

Indications

Doxin Capsule is used for: Anxiety disorders, Depression, Insomnia

Adult Dose

Oral Depression/Anxiety Adult: Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose If dose exceeds 150 mg/day, divide q12hr Hepatic impairment: Use lower dose and adjust gradually for depression; Insomnia (Silenor) Sleep maintenance 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime Elderly Insomnia Sleep maintenance Starting dose: 3 mg PO within 30 minutes before bedtime May increase to 6 mg PO HS if clinically indicated Depression/Anxiety Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated

Child Dose

<12 years old: Not recommended

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity; mania, glaucoma, neonates (topical); lactation.

Precautions

Epilepsy, CV disease, pregnancy, history of urinary retention, glaucoma; gradual withdrawal. May impair ability to drive or operate machinery. Lactation: Enters breast milk; not recommended (AAP states "may be of concern")

Pregnancy-Lactation

Interactions

Methylphenidate may increase plasma doxepin levels. Potentially Fatal: Potentiates hypertensive action of sympathomimetics. Increased anticholinergic effects with MAOIs. Additive CNS effects with anticholinergics, CNS depressants and alcohol.

Adverse Effects

Side effects of Doxepin : Sedation, fatigue, weakness, lethargy,Dry mouth,Constipation,Blurred vision,Headache,Agitation,Insomnia,Anxiety,Nausea, vomiting,Sweating,Confusion, extrapyramidal symptoms (EPS), dizziness, paresthesia,Orthostatic hypotension, ECG changes, tachycardia,Increased LFTs,Tinnitus,Sexual dysfunction,Rash,Seizure,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,SIADH

Mechanism of Action

Doxepin inhibits serotonin and norepinephrine re-uptake by the presynaptic neuronal membrane increasing its synaptic conc in the CNS.

Note

Doxin 25mg Capsule manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Doxepin. Doxin is availble in Nepal. Farmaco Nepal drug index information on Doxin Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Doxepin :