Duolin Respules 0.5 Respules
Levalbuterol
0.5mg
Cipla Ltd.
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Indications
Duolin Respules 0.5 Respules is used for:
Bronchospasm, Asthma Exacerbation
Adult Dose
Adult
Bronchospasm
Nebulizer solution: 0.63-1.25 mg 3 times daily q6-8hr
Aerosol: 90 mcg (2 actuations of metered-dose inhaler) q4-6hr
Asthma Exacerbation
Nebulizer solution: 1.25-2.5 mg q20min for 3 doses, then 1.25-5 mg q1-4hr PRN
Aerosol: 180-360 mcg (4-8 actuations of metered-dose inhaler) q20min for ?4 hr, then q1-4hr PRN
Child Dose
Child
Bronchospasm
Nebulizer solution
<5 years: 0.31-1.25 mg q4-6hr PRN
5-12 years: 0.31 mg q8hr; not to exceed 0.63 mg q8hr PRN
>12 years: 0.63-1.25 mg q8hr PRN
Aerosol
<4 years: Safety and efficacy not established
>4 years: 90 mcg (2 actuations of metered-dose inhaler) q4-6hr PRN
Asthma Exacerbation
Nebulizer solution
<12 years: 0.075 mg/kg (?1.25 mg) q20min for 3 doses, then 0.075-0.15 mg/kg (?5 mg) q1-4hr PRN
>12 years: 1.25-2.5 mg q20min for 3 doses, then 1.25-5 mg q1-4hr PRN
Aerosol
<4 years: Safety and efficacy not established
>4 years: 180-360 mcg (4-8 actuations of metered-dose inhaler) q20min for 3 doses, then q1-4hr PRN
Renal Dose
Administration
Contra Indications
Hypersensitivity to levalbuterol or racemic albuterol
Precautions
Cardiovascular disorder (eg, arrhythmias, hypertension, coronary insufficiency)
Risk of paradoxical bronchospasm
Has higher affinity for beta1- and beta2-adrenergic receptors than racemic albuterol has
Risk of hypersensitivity reactions
Use with caution in diabetes mellitus (beta2 agonists may increase glucose)
Risk of hypokalemia (usually transient)
Lactation
There are no available data on presence of levalbuterol in human milk, effects on breastfed child, or effects on milk production
Developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Levalbuterol :
>10%
Headache (8-12%)
Viral infection (7-12%)
Rhinitis (3-11%)
1-10%
Pharyngitis (3-10%)
Tremor (7%)
Sinusitis (1-4%)
Flu (1-4%)
Dyspepsia (1-3%)
Leg cramps (<3%)
Generalized pain (2.8%)
Nasal edema (2.8%)
Nervousness (2.8%)
Tachycardia (2.8%)
Postmarketing Reports
Dysphonia
Gastroesophageal reflux disease, nausea
Angioedema, anaphylaxis, rash, urticaria
Chest pain, tachycardia, arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles)
Asthma, increased cough, dyspnea, dysphonia
Metabolic acidosis
Nervousness, tremor
Mechanism of Action
Beta2-receptor agonist with some beta1 activity; relaxes bronchial smooth muscle
Note
Duolin Respules 0.5 0.5mg Respules manufactured by Cipla Ltd.. Its generic name is Levalbuterol. Duolin Respules 0.5 is availble in Nepal.
Farmaco Nepal drug index information on Duolin Respules 0.5 Respules is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.