Duotax Tablet
Cefotaxime + Sulbactam
1gm + 500mg
Aristo Pharmaceuticals Ltd.
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| Retail Price | 71.76 NPR |
Indications
Duotax Tablet is used for:
Genitourinary infections, Lower respiratory tract infections
Adult Dose
Oral
Genitourinary infections, Lower respiratory tract infections
Adult: Mild to moderate infections: 1/0.5 g to 2/1 g of cefotaxime/sulbactam every 8-12 hrs. Moderate to severe infections: 1/0.5 g to 2/1 g of cefotaxime/sulbactam every 6-8 hrs. Max (sulbactam): 4 g.
Child Dose
Oral
Genitourinary infections, Lower respiratory tract infections
Child: 100/50 mg to 150/75 mg of cefotaxime/sulbactam /kg/day in 3 divided doses. Life-threatening infections: Dose of cefotaxime may be increased up to 12 g/day.
Max Dosage: Max (sulbactam): Sulbactam: Adult: 4 g. Child: 80 mg/kg/day in divided doses.
Renal Dose
Renal impairment: Dose adjustment may be needed.
Administration
Contra Indications
Hypersensitivity to cefotaxime, sulbactam or the combination.
Precautions
Previous hypersensitivity to penicillins or other drugs; patients with renal insufficiency; history of GI disease, esp colitis. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Cefotaxime + Sulbactam :
Skin rash, diarrhoea, nausea, vomiting and colitis.
Mechanism of Action
Cefotaxime is a bactericidal drug, which inhibits the bacterial wall synthesis of the actively dividing cells by binding to one or more penicillin-binding proteins.
Sulbactam is a semisynthetic beta-lactam sulphone, which inhibits beta-lactamases of the Richmond types II, III, IV and V (plasmid or chromosomally mediated). This inhibition is reported to be both reversible and irreversible. It acts as a suicide inhibitor by forming a reversible inactive enzyme-sulbactam complex. This reversible acyl-intermediate may then revert to a more stable complex, which irreversibly inhibits the beta-lactamase.
Sulbactam is able to protect the activity of various β-lactam antibiotics by rendering β-lactamases inactive.
Note
Duotax 1gm + 500mg Tablet manufactured by Aristo Pharmaceuticals Ltd.. Its generic name is Cefotaxime + Sulbactam. Duotax is availble in Nepal.
Farmaco Nepal drug index information on Duotax Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.