E Pril 2.5 Tablet
Enalapril Maleate
2.5mg
Time Pharmaceuticals Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.50 NPR |
Available as:
Indications
E Pril 2.5 Tablet is used for:
Hypertension, Heart failure
Adult Dose
Hypertension
Oral
Initial: 2.5-5 mg PO qDay
Maintenance: 10-40 mg/day PO qDay or divided q12hr
Left Ventricular Dysfunction
Initial: 2.5 mg PO q12hr
May titrate up to 20 mg/day
Congestive Heart Failure
Initial: 2.5 mg PO qDay or q12hr
Maintenance: 5-40 mg/Day PO divided q12hr; titrate slowly q2Weeks
Hepatic impairment: No dosage adjustment required
Child Dose
Hypertension
1 month to 16 years (oral)
Initial: 0.08 mg/kg/day PO or divided q12hr; not to exceed 5 mg/day
May increase PRN q2Weeks according to blood pressure not to exceed 0.58 mg/kg/day (or 40 mg/day)
Renal Dose
Renal impairment
CrCl <30 mL/min: (PO) Initiate 2.5 mg; titrate to response; not to exceed 40 mg
Dialysis: 2.5 mg PO on day of dialysis; adjust dose on nondialysis days according to BP
CrCl <30 mL/min: (IV) Initiate 0.625 mg q6hr; titrate based on response
CrCl ?30 mL/min: (PO) Initiate 5 mg/day; titrate to maximum of 40 mg
CrCl ?30 mL/min: (IV) 1.25 mg q6hr; titrate based on response
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. History of angioedema due to previous treatment with ACE inhibitors; bilateral renal artery stenosis. Pregnancy.
Precautions
Impaired renal function. Hyperkalaemia, hypovolaemia, collagen vascular disease, valvular stenosis, during or immediately before or after anaesthesia, unilateral renal artery stenosis. Hypotension due to volume depletion, diuretic therapy. Monitor WBC count. Lactation, children.
Pregnancy-Lactation
Pregnancy category: C (1st trimester); D (2nd and 3rd trimesters). During the second and third trimesters of pregnancy, these drugs have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible and irreversible renal failure, and death
Interactions
May potentiate hypotensive action w/ diuretics, other antihypertensives, TCAs, nitrates or anaesth. Concomitant admin w/ lithium carbonate may cause lithium toxicity. Increased risk of renal impairment w/ NSAIDs. May increase hyperkalaemic effect w/ K-sparing diuretics and supplements.
Adverse Effects
Side effects of Enalapril Maleate :
1-10%
Dizziness (4-8%),Hypotension (0.9-6.7%),Headache (2-5%),Chest pain (2%),Cough (1-2%),Rash (1.5%)
Frequency Not Defined
Asthenia,Nausea,Vomiting,Hyperkalemia
Potentially Fatal: Angioedema.
Mechanism of Action
Enalapril, a prodrug of enalaprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation and BP reduction.
Note
E Pril 2.5 2.5mg Tablet manufactured by Time Pharmaceuticals Pvt. Ltd.. Its generic name is Enalapril Maleate. E Pril 2.5 is availble in Nepal.
Farmaco Nepal drug index information on E Pril 2.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.