Econex Tablet
Isoniazid + Ethambutol
800mg + 300mg
Macleods Pharmaceuticals Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
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| Retail Price | 8.51 NPR |
Indications
Econex Tablet is used for:
Tuberculosis
Adult Dose
Oral
Adult
800 mg ethambutol and 300 mg isoniazid, as a single daily dose
Ethambutol and isoniazid in a fixed-dose combination should not be used in the initial phase of tuberculosis treatment {01}. Ethambutol and isoniazid in a fixed-dose combination can be substituted for thioacetazone and isoniazid combination in patients with side effects due to thioacetazone. Full course of therapy, which may take 6 months to 2 years.
Child Dose
Child < 14 years of age: Safety & efficacy has not been established.
Renal Dose
Patients with impaired renal function generally do not require a reduction in dose if the plasma creatinine concentration is less than 6 mg per 100 mL. If renal impairment is more severe or if patients are slow acetylators, a reduction in dose and/or serum determinations may be required.
Administration
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity. Patient w/ acute liver disease or a history of isoniazid-associated hepatic injury. Patient w/ known optic neuritis and poor vision.
Precautions
Patient w/ convulsive disorders, history of psychosis. Patient at risk of neuropathy (e.g. diabetics, alcoholics, malnourished, uraemic, infected w/ HIV) or pyridoxine deficiency. Patient w/ ocular defects (e.g. cataracts, recurrent ocular inflammatory conditions, diabetic neuropathy). Hepatic and severe renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor baseline and periodic LFTs (ALT and AST), sputum cultures mthly until 2 consecutive negative cultures reported and prodromal signs of hepatitis.
Pregnancy-Lactation
Interactions
Inhibit the hepatic metabolism of antiepileptics (e.g. carbamazepine, ethosuximide, primidone, phenytoin), benzodiazepines (e.g. diazepam, triazolam), chlorzoxazone, theophylline, disulfiram, sometimes leading to increased toxicity. Increased metabolism of enflurane, resulting in potentially nephrotoxic levels of fluoride. Increased concentrations and enhanced effects or toxicity of clofazimine, cycloserine and warfarin. Reduced absorption w/ Al-containing antacids. Increased risk of peripheral neuropathy w/ zalcitabine and stavudine.
Adverse Effects
Side effects of Isoniazid + Ethambutol :
Peripheral neuritis, psychotic reactions, convulsions, optic neuritis, transient increases in liver enzymes; haematological effects (e.g. anaemias, agranulocytosis, thrombocytopenia, eosinophilia); hypersensitivity reactions include skin eruptions (including erythema multiforme), fever, vasculitis; nausea, vomiting, dry mouth, constipation, pellagra, purpura, hyperglycaemia, lupus-like syndrome, vertigo, hyperreflexia, urinary retention, gynaecomastia. Retrobulbar neuritis w/ reduction in visual acuity, constriction of visual field, central or peripheral scotoma and green-red colour blindness of 1 or both eyes.
Potentially Fatal: Hepatitis.
Mechanism of Action
Isoniazid inhibits the synthesis of mycoloic acids in susceptible bacteria which results in loss of acid-fastness and disruption of bacterial cell wall. At therapeutic levels, it is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.
Ethambutol appears to inhibit the synthesis of 1 or more metabolites in susceptible bacteria resulting in impairment of cellular metabolism, arrest of multiplication, and cell death. It is active against susceptible bacteria only when they are undergoing cell division.
Note
Econex 800mg + 300mg Tablet manufactured by Macleods Pharmaceuticals Pvt. Ltd.. Its generic name is Isoniazid + Ethambutol. Econex is availble in Nepal.
Farmaco Nepal drug index information on Econex Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.