Efnate Cream
Clobetasone butyrate 0.05% Topical
0.05%W/W
National Healthcare Pvt. Ltd.
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| Retail Price | 90.00 NPR |
Indications
Efnate Cream is used for:
Inflammatory skin disorders. All types of eczema & dermatitis, including atopic eczema, photodermatitis, otitis externa, primary irritant & allergic dermatitis (napkin rash), prurigo nodularis, seborrhoeic dermatitis & insect bite reactions.
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: Use as 0.05% cream or ointment to be applied thinly once or bid on affected areas.
This medicine should not be used every day for more than 4 weeks at a time.
Child Dose
Renal Dose
Administration
Wash hands and dry them
Squeeze out the correct amount of cream onto index finger.
Half a fingertip will cover a patchnof skin the same size as the palm of hand.
Gently rub the cream into the skin area that are treating.
Wash hands again (unless it is your hands you are treating).
Contra Indications
Pregnancy (in high doses). Presence of acute infections. Treatment of rosacea; leg ulcers; acne vulgaris; widespread plaque psoriasis. Child <1 yr.
Precautions
May be absorbed in sufficient amounts to cause systemic effects when applied topically to large areas, broken skin or under occlusive dressings. Peptic ulcer, osteoporosis, psychoses or severe psychoneuroses. Not to be used indiscriminately for pruritus. CHF or hypertension. Diabetes mellitus, epilepsy, glaucoma, infectious diseases, ocular herpes simplex, chronic renal failure and uraemia. Active or doubtfully quiescent tuberculosis. Local treatment of eye disorders. Elderly. Prolonged use on the face.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clobetasone butyrate 0.05% Topical :
Local atrophic changes; pigmentation changes & hypertrichosis. Increased liability to infection. Infections may be masked. Acute adrenal insufficiency. Growth retardation in child. Cushingoid symptoms. Amenorrhoea, hyperhidrosis, skin thinning,
Mechanism of Action
Clobetasone butyrate is classed as a moderately potent topical corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.
Note
Efnate 0.05%W/W Cream manufactured by National Healthcare Pvt. Ltd.. Its generic name is Clobetasone butyrate 0.05% Topical. Efnate is availble in Nepal.
Farmaco Nepal drug index information on Efnate Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.