Ensamycin Cream

Sisomicin Topical
1mg
Fulford India Ltd.
Pack size 15
Dispensing mode
Source
Agent
Retail Price 83.52 NPR

Indications

Ensamycin Cream is used for:

Adult Dose

Topical/Cutaneous Pyoderma Adult: As 0.1% cream: Apply onto the affected area(s) bid.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Renal or liver impairment, myasthenia gravis, parkinsonism, dehydration, hypotension, pregnancy, lactation.

Pregnancy-Lactation

Interactions

Plasma levels increased by indometacin. Antihistamines (H1-receptor blocker) may mask early signs of ototoxicity. Incompatible with some β-lactam antibiotics. Potentially Fatal: Potentiates nephrotoxicity produced by other nephrotoxic drugs including other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid. Ototoxicity potentiated by furosemide.

Adverse Effects

Side effects of Sisomicin Topical : Ototoxicity, nephrotoxicity, neurotoxicity (peripheral neuropathy, confusion, lethargy, hallucination, convulsion and mental depression, occasional respiratory depression), rarely hypersensitivity reaction. Potentially Fatal: Acute renal failure especially in combination with other nephrotoxic drugs.

Mechanism of Action

Sisomicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Note

Ensamycin 1mg Cream manufactured by Fulford India Ltd.. Its generic name is Sisomicin Topical. Ensamycin is availble in Nepal. Farmaco Nepal drug index information on Ensamycin Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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