Entamizole Plus Tablet
Ornidazole
500mg
Abbott India Ltd.
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Indications
Entamizole Plus Tablet is used for:
Amoebiasis, Hereditary angioedema, Trichomoniasis, Anaerobic bacterial infections, Amoebic dysentery, Surgical Prophylaxis,
Adult Dose
Oral
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Hepatic impairment: Severe: Double the interval between doses.
Child Dose
Oral
Amoebiasis
Child: 25 mg/kg as a single daily dose for 5-10 days.
Amoebic dysentery
Child: 40 mg/kg daily.
Giardiasis
Child: 30-40 mg/kg daily.
Trichomoniasis
Child: 25 mg/kg as a single dose.
Renal Dose
Renal impairment: Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to ornidazole or to other nitroimidazole derivatives.
Precautions
Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.
Adverse Effects
Side effects of Ornidazole :
Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
Mechanism of Action
Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Note
Entamizole Plus 500mg Tablet manufactured by Abbott India Ltd.. Its generic name is Ornidazole. Entamizole Plus is availble in Nepal.
Farmaco Nepal drug index information on Entamizole Plus Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.