Entosec Tablet
Secnidazole
1gm
Cipla Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 58.46 NPR |
Indications
Entosec Tablet is used for:
Giardiasis, Amoebiasis, Trichomoniasis
Adult Dose
Oral
Trichomoniasis; Amoebiasis; Giardiasis
Adult: 2 g as a single dose.
Severe invasive amoebiasis
Adult: 1.5 g daily as single or in divided doses for 5 days.
Child Dose
Oral
Trichomoniasis; Amoebiasis; Giardiasis
Child: 30 mg/kg as a single dose.
Severe invasive amoebiasis
Child: 30 mg/kg daily for 5 days.
Renal Dose
Administration
Contra Indications
Hypersensitivity; pregnancy (1st trimester) and lactation.
Precautions
Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
Pregnancy-Lactation
Interactions
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.
Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.
Adverse Effects
Side effects of Secnidazole :
Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
Mechanism of Action
Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
Note
Entosec 1gm Tablet manufactured by Cipla Ltd.. Its generic name is Secnidazole. Entosec is availble in Nepal.
Farmaco Nepal drug index information on Entosec Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.