Epiduo Gel
Adapalene 0.1% + Benzoyl Peroxide 2.5%
0.1% W/W + 2.5%W/W
Galderma Ltd.
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Retail Price | 734.86 NPR |
Indications
Epiduo Gel is used for:
Acne
Adult Dose
Apply a thin film of adapalene and benzoyle peroxide gel to affected areas of the face and/or trunk once daily after washing.
Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek).
Avoid the eyes, lips and mucous membranes.
Child Dose
Child: >9 years: Apply thin film to affected facial areas and/or trunk qPM after washing
<9 years: Safety & efficacy has not been established.
Renal Dose
Administration
Contra Indications
Hypersensitive to any of the components.
Precautions
Exposure to sunlight, including sunlamps, should be minimized during the use of adapalene and benzoyle peroxide gel. Patients with high levels of sun exposure and those with inherent sensitivity to sun should exercise particular caution. Use of sunscreen products and protective apparel, (e.g., hat) are recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, may be irritating to patients under treatment with adapalene and benzoyle peroxide gel.
Safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 9 years have not been established.
Pregnancy-Lactation
Interactions
Adapalene: Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.
Benzoyl Peroxide: PABA sunscreens may transiently discolour fabric.
Adverse Effects
Side effects of Adapalene 0.1% + Benzoyl Peroxide 2.5% :
>10%
Stinging/ burning (3-41%),Dryness (1-41%),Scaling (1-35%),Erythema (1-27%)
1-10%
Contact dermatitis (3%),Application site burning (2%),Application site irritation (1%),Skin irritation (1%)
Mechanism of Action
Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its oxidative property. It is active against S.epidermidis and P.acne.
Note
Epiduo 0.1% W/W + 2.5%W/W Gel manufactured by Galderma Ltd.. Its generic name is Adapalene 0.1% + Benzoyl Peroxide 2.5%. Epiduo is availble in Nepal.
Farmaco Nepal drug index information on Epiduo Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.