Epiduo Gel

Adapalene 0.1% + Benzoyl Peroxide 2.5%
0.1% W/W + 2.5%W/W
Galderma Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 734.86 NPR

Indications

Epiduo Gel is used for: Acne

Adult Dose

Apply a thin film of adapalene and benzoyle peroxide gel to affected areas of the face and/or trunk once daily after washing. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Avoid the eyes, lips and mucous membranes.

Child Dose

Child: >9 years: Apply thin film to affected facial areas and/or trunk qPM after washing <9 years: Safety & efficacy has not been established.

Renal Dose

Administration

Contra Indications

Hypersensitive to any of the components.

Precautions

Exposure to sunlight, including sunlamps, should be minimized during the use of adapalene and benzoyle peroxide gel. Patients with high levels of sun exposure and those with inherent sensitivity to sun should exercise particular caution. Use of sunscreen products and protective apparel, (e.g., hat) are recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, may be irritating to patients under treatment with adapalene and benzoyle peroxide gel. Safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 9 years have not been established.

Pregnancy-Lactation

Interactions

Adapalene: Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents. Benzoyl Peroxide: PABA sunscreens may transiently discolour fabric.

Adverse Effects

Side effects of Adapalene 0.1% + Benzoyl Peroxide 2.5% : >10% Stinging/ burning (3-41%),Dryness (1-41%),Scaling (1-35%),Erythema (1-27%) 1-10% Contact dermatitis (3%),Application site burning (2%),Application site irritation (1%),Skin irritation (1%)

Mechanism of Action

Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its oxidative property. It is active against S.epidermidis and P.acne.

Note

Epiduo 0.1% W/W + 2.5%W/W Gel manufactured by Galderma Ltd.. Its generic name is Adapalene 0.1% + Benzoyl Peroxide 2.5%. Epiduo is availble in Nepal. Farmaco Nepal drug index information on Epiduo Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Adapalene 0.1% + Benzoyl Peroxide 2.5% :