Eraxis Injection
Anidulafungin
Pfizer Ltd.
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| Retail Price | 15988.65 NPR |
Indications
Eraxis Injection is used for:
Oesophageal candidiasis, Invasive candidiasis, Candidaemia, Candida infections (intra-abdominal abscess, pertonitis)
Adult Dose
Intravenous
Oesophageal candidiasis
Adult: Loading dose of 100 mg on day 1, then 50 mg once daily thereafter. Continue treatment for at least 14 days and for at least 7 days following resolution of symptoms. To be given by IV infusion. Max infusion rate: 1.1 mg/min.
Elderly: No dosage adjustment needed.
Intravenous
Invasive candidiasis, Candidaemia, Candida infections (intra-abdominal abscess, pertonitis)
Adult: Loading dose of 200 mg on day 1, then 100 mg once daily thereafter. Continue treatment for at least 14 days after the last positive culture. To be given by IV infusion. Max infusion rate: 1.1 mg/min.
Elderly: No dosage adjustment needed.
Child Dose
Renal Dose
Administration
IV Preparation
Aseptically reconstitute each 50 mg vial with 15 mL supplied diluent to obtain a 3.33 mg/mL solution
Administer within 24 hr post-reconstitution
Dilute further by transferring aseptically in a bag or bottle containing D5W or 0.9% NaCl to provide an infusion solution of 0.5 mg/mL
Discard if particulate matter or discoloration appears
IV Administration
IV infusion rate: Not to exceed 1.1 mg/min
Do not give as IV bolus
Contra Indications
Hypersensitivity to anidulafungin or other echinocandins.
Precautions
Patients w/ serious underlying conditions receiving multiple concomitant medications w/ anidulafungin may experience hepatic abnormalities e.g. hepatitis, hepatic dysfunction or worsening hepatic failure. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Anidulafungin :
Infusion-related reactions (e.g. pruritus, urticaria, rash, hypotension, dyspnoea, flushing); nausea, diarrhoea; phlebitis/thrombophlebitis, neutropaenia, hypokalaemia, headache; elevated alkaline phosphatase, hepatic enzymes, and γ-glutamyltransferase.
Mechanism of Action
Anidulafungin is a semi-synthetic echinocandin antifungal. Echinocandin - inhibits synthesis of 1,3-beta-D-glucan, an essential component of fungal cell walls.
Note
Eraxis Injection manufactured by Pfizer Ltd.. Its generic name is Anidulafungin. Eraxis is availble in Nepal.
Farmaco Nepal drug index information on Eraxis Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.