Indications
Esta Spray is used for:
Moderate to severe vasomotor symptoms associated with menopause, Prophylaxis of osteoporosis in postmenopausal women, Hypogonadism, Atrophic vaginitis
Adult Dose
Oral
Vulvar and Vaginal Atrophy in Menopause
Adult: 1-2 mg PO once daily for 3 weeks, followed by 1 week off
Prevention of osteoporosis:
0.5 mg PO once daily for 3 weeks, followed by 1 week off
Metastatic breast cancer:
10 mg PO q8hr for 3 months
Prostate cancer:
1-2 mg PO q8hr for ?3 months
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity; undiagnosed vag bleeding; thrombophloebitis or thromboembolic disorders; breast carcinoma except in selected patients being treated for metastatic disease; oestrogen-dependent tumor; porphyria; pregnancy.
Precautions
Conditions exacerbated by fluid retention; hypercalcaemia, cerebrovascular diorders, coronary artery disease, gall bladder diseases; lipid effects; familial defects of lipoprotein metabolism. May increase BP, risk of venous thromboembolism, breast cancer, benign hepatic adenoma, endometrial cancer and size of preexisting uterine leiomyomata. Dosage should be reduced in hepatic impairment. Lactation. Child.
Lactation: Drug enters breast milk; use with caution
Pregnancy-Lactation
Interactions
CYP1A2 and CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together.
Adverse Effects
Side effects of Estradiol :
Anxiety,Abdominal cramping,Amenorrhea,Bloating,Breakthrough bleeding,Breast enlargement,Breast tenderness,Delayed ejaculation,Depression,Dry mouth,Headache,Hypertension,Impotency,Influenza,Leukorrhea,Melasma,Muscle cramps,Nausea,Nervousness,Peripheral edema,Polydipsia,Pruritus,Rash,Swelling,Spotting,Syncope,Toothache,Vaginal discomfort, vaginal erosion, vaginal ulceration, adherence of the vaginal ring to the vaginal wall (Estring),Vomiting,Weight changes
Mechanism of Action
Estradiol is a naturally occurring oestrogen. Oestrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH and FSH through a negative feedback system.
Note
Esta 0.375mg Spray manufactured by Cipla Ltd.. Its generic name is Estradiol. Esta is availble in Nepal.
Farmaco Nepal drug index information on Esta Spray is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.