Ethyol Injection
Amifostine
500mg
Fulford India Ltd.
| Pack size | 1 |
|---|---|
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Indications
Ethyol Injection is used for:
Nephrotoxicity (Indicated to reduce cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer), Xerostomia
Adult Dose
Nephrotoxicity
910 mg/m² IV (15-minute infusion), 30 minutes before chemotherapy
Blood pressure should be followed following its administration and interrupted if systolic blood pressure decreases signficantly from baseline
Xerostomia
200 mg/m² IV (3-minute infusion), 15-30 minutes before radiation therapy
500 mg SC qDay prior to radiation therapy
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Ensure adequate hydration and premedicate with antiemetic treatment
IV Preparation
Reconstitute with 9.5 mL 0.9% NaCl
Amifostine should be further diluted in 0.9% NaCl to a concentration of 5-40 mcg/mL
IV Administration
Infuse over 15 min before chemotherapy
Infuse over 3 min before radiation treatment
Administration as a longer infusion is associated with a higher incidence of adverse effects
Contra Indications
Hypersensitivity to aminothiol, monitor closely during and after IV
Precautions
Patients should be adequately hydrated prior to the Amifostine for Injection infusion and blood pressure should be monitored
Cardiovascular disease, hypocalcemia, hypotension, cutaneous reactions, or nausea/vomiting may occur
Ensure adequate hydration
Do not give to patients receiving definitive radiotherapy except in the context of a clinical trial, since there are at present insufficient data to exclude a tumor-protective effect in this setting; amifostine was studied only with standard fractionated radiotherapy and only when ≥75% of both parotid glands were exposed to radiation
Use caution in hypotension and cerebrovascular disease
Interrupt antihypertensive therapy 24 hr before treatment; patients unable to safely interupt antihypertensive therapy should not recieve amifostine
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Interactions
Special consideration should be given to the administration of Amifostine for Injection in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.
Adverse Effects
Side effects of Amifostine :
>10%
Nausea/vomiting (96%),Hypotension (61%) - discontinue infusion if significant BP drop
1-10%
Hypocalcemia (1%),Stevens-Johnson syndrome (1%)
Frequency Not Defined
Chills/feeling of coldness,Flushing/feeling of warmth,Dizziness,Fever,Somnolence,Rash,Malaise,Hiccups,Sneezing
Mechanism of Action
Thiol metabolite binds to reactive metabolites of cisplatin and scavenges free radicals
Note
Ethyol 500mg Injection manufactured by Fulford India Ltd.. Its generic name is Amifostine. Ethyol is availble in Nepal.
Farmaco Nepal drug index information on Ethyol Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.