Ethyol Injection

Amifostine
500mg
Fulford India Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price

Indications

Ethyol Injection is used for: Nephrotoxicity (Indicated to reduce cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer), Xerostomia

Adult Dose

Nephrotoxicity 910 mg/m² IV (15-minute infusion), 30 minutes before chemotherapy Blood pressure should be followed following its administration and interrupted if systolic blood pressure decreases signficantly from baseline Xerostomia 200 mg/m² IV (3-minute infusion), 15-30 minutes before radiation therapy 500 mg SC qDay prior to radiation therapy

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Ensure adequate hydration and premedicate with antiemetic treatment IV Preparation Reconstitute with 9.5 mL 0.9% NaCl Amifostine should be further diluted in 0.9% NaCl to a concentration of 5-40 mcg/mL IV Administration Infuse over 15 min before chemotherapy Infuse over 3 min before radiation treatment Administration as a longer infusion is associated with a higher incidence of adverse effects

Contra Indications

Hypersensitivity to aminothiol, monitor closely during and after IV

Precautions

Patients should be adequately hydrated prior to the Amifostine for Injection infusion and blood pressure should be monitored Cardiovascular disease, hypocalcemia, hypotension, cutaneous reactions, or nausea/vomiting may occur Ensure adequate hydration Do not give to patients receiving definitive radiotherapy except in the context of a clinical trial, since there are at present insufficient data to exclude a tumor-protective effect in this setting; amifostine was studied only with standard fractionated radiotherapy and only when ≥75% of both parotid glands were exposed to radiation Use caution in hypotension and cerebrovascular disease Interrupt antihypertensive therapy 24 hr before treatment; patients unable to safely interupt antihypertensive therapy should not recieve amifostine Lactation: excretion in milk unknown/not recommended

Pregnancy-Lactation

Interactions

Special consideration should be given to the administration of Amifostine for Injection in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.

Adverse Effects

Side effects of Amifostine : >10% Nausea/vomiting (96%),Hypotension (61%) - discontinue infusion if significant BP drop 1-10% Hypocalcemia (1%),Stevens-Johnson syndrome (1%) Frequency Not Defined Chills/feeling of coldness,Flushing/feeling of warmth,Dizziness,Fever,Somnolence,Rash,Malaise,Hiccups,Sneezing

Mechanism of Action

Thiol metabolite binds to reactive metabolites of cisplatin and scavenges free radicals

Note

Ethyol 500mg Injection manufactured by Fulford India Ltd.. Its generic name is Amifostine. Ethyol is availble in Nepal. Farmaco Nepal drug index information on Ethyol Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Amifostine :