Eumosone M Cream
Clobetasol + Miconazole Topical
0.05% w/w + 2% w/w
Glaxo SmithKline Pharmaceuticals Ltd.
| Pack size | 15gm |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 89.92 NPR |
Available as:
Indications
Eumosone M Cream is used for:
Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection
Adult Dose
Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection
Cream: Apply thin layer to affected areas q12hr and rub in gently and completely
Child Dose
Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection
<12 years
Safety & efficacy not established
>12 years: Cream: Apply thin layer to affected areas q12hr and rub in gently and completely
Renal Dose
Administration
Contra Indications
Childn <12 yrs. Long-term treatment of ulcerative conditions, rosacea, pruritus; It is contraindicated in rosacea, acne vulgaris, perioral dermatitis, primary cutaneous viral infections (eg. herpes simplex, chickenpox). Hypersensitivity to the preparations.
Precautions
Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clobetasol + Miconazole Topical :
Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura. Burning, Cracking/fissuring of the skin, Erythema, Folliculitis, Irritation, Numbness, Pruritus, Stinging, Hypopigmentation (high potency topical steroids)
Potentially Fatal: Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.
Mechanism of Action
Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Note
Eumosone M 0.05% w/w + 2% w/w Cream manufactured by Glaxo SmithKline Pharmaceuticals Ltd.. Its generic name is Clobetasol + Miconazole Topical. Eumosone M is availble in Nepal.
Farmaco Nepal drug index information on Eumosone M Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.