Evalon Cream
Estradiol 0.06% vag prep
MSD Pharmaceuticals Pvt Ltd
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 462.40 NPR |
Indications
Evalon Cream is used for:
Vulvular and vaginal atrophy, Atrophic vaginitis
Adult Dose
Vaginal
Vulvular and vaginal atrophy
Adult: Insert 2-4 g/day of vag cream intravaginally for 2 wk, then reduce gradually to half the initial dose for 2 wk followed by a maintenance dose of 1 g 1-3 times/wk.
Postmenopausal vaginal atrophy
Adult: Insert a vag ring containing 2 mg of estradiol and keep in place for 90 days.
Urogenital symptoms
Adult: Insert a vag ring containing 2 mg of estradiol and keep in place for 90 days.
Atrophic vaginitis
Adult: Initial: Insert 1 tab (20 mcg) once daily for 2 wk. Maintenance: Insert 1 tab twice wkly. Attempt to discontinue or taper medication at 3-6 mthly intervals.
Child Dose
Renal Dose
Administration
Intravaginal Administration
Intravaginal ring
Insert in upper third of vaginal vault; the ring is to remain in place continuously for 3 months, after which it is to be removed and, if appropriate, replaced by a new ring
Should the ring be removed or fall out at any time during the 90-day treatment period, rinse the ring in lukewarm water and reinsert (by the patient, or, if necessary, by a physician or nurse)
Vaginal tablet or cream
Use applicator provided with drug to insert vaginal tablet or measure dose of vaginal cream
Lay on back with pelvis slightly tilted upward, or stand with one knee bent (ie, foot on seat of chair or toilet), insert the prescribed dose with applicator
The applicator should be inserted (without forcing) as far as comfortably possible, or until half of the applicator is inside vagina
Note: The vaginal tablet dissolves gradually over several hours, so bedtime application may be desired
Contra Indications
Hypersensitivity; undiagnosed vag bleeding; thrombophloebitis or thromboembolic disorders; breast carcinoma except in selected patients being treated for metastatic disease; oestrogen-dependent tumor; porphyria; pregnancy.
Precautions
Conditions exacerbated by fluid retention; hypercalcaemia, cerebrovascular diorders, coronary artery disease, gall bladder diseases; lipid effects; familial defects of lipoprotein metabolism. May increase BP, risk of venous thromboembolism, breast cancer, benign hepatic adenoma, endometrial cancer and size of preexisting uterine leiomyomata. Dosage should be reduced in hepatic impairment. Lactation. Child.
Lactation
Should not be used during lactation; estrogen administration to nursing women has been shown to decrease the quantity and quality of the breast milk
Caution should be exercised when estrogen is administered to a nursing woman
Pregnancy-Lactation
Interactions
CYP1A2 and CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together.
Adverse Effects
Side effects of Estradiol 0.06% vag prep :
>10%
Headache (9-16%)
1-10%
Vulvovaginal mycotic infection (5-8%),Vulvovaginal pruritus (8%),Back pain (7%),Abdominal pain (7%),Diarrhea (5%)
Mechanism of Action
Estradiol is a naturally occurring oestrogen. Oestrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH and FSH through a negative feedback system.
Note
Evalon Cream manufactured by MSD Pharmaceuticals Pvt Ltd. Its generic name is Estradiol 0.06% vag prep. Evalon is availble in Nepal.
Farmaco Nepal drug index information on Evalon Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.