Expectryl Syrup
Pheniramine Maleate
Sumy Pharmaceuticals Pvt. Ltd.
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Indications
Expectryl Syrup is used for:
Allergic conditions, Motion sickness, Allergic conjunctivitis, Allergic rhinitis
Adult Dose
Oral
Allergic conditions
Adult:
Syrup: 15-30 mg bid or tid.
Tablet: Up to 45 mg tid.
Max: 3 mg/kg/day.
Elderly: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day.
Prophylaxis of motion sickness
Adult:
Syrup: 15-30 mg bid or tid.
Tablet: Up to 45 mg tid. Max: 3 mg/kg/day.
Take 1st dose at least 30 min before travelling.
Child Dose
Oral
Allergic conditions
Child:
Tablet
5-10 yr: Half a 45-mg tablet up to tid; Tablet: Up to 45 mg tid.
>10 yr: Syrup: 15-30 mg bid or tid.
Max: 3 mg/kg/day.
Prophylaxis of motion sickness
Child: As maleate: 5-10 yr: Half a 45-mg tablet up to tid; >10 yr: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling.
Renal Dose
Administration
Should be taken with food. Take after meals.
Contra Indications
Symptomatic prostatic hypertrophy; neonates and premature infants.
Precautions
May impair ability to drive or operate machinery. Has potential for abuse. Narrow angle glaucoma, asthma or severe CV disease. Antiemetic effect may mask signs of other conditions. Pregnancy and lactation. Elderly.
Pregnancy-Lactation
Interactions
May mask ototoxicity produced by aminoglycoside antibiotics.
Potentially Fatal: Potentiation of CNS depression by alcohol, sedatives, opioids, barbiturates, hypnotics, narcoleptics. May increase antimuscarinic effect of MAOIs, atropine and TCAs.
Adverse Effects
Side effects of Pheniramine Maleate :
Sedation. Hypersensitivity reactions. Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors. Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation. Urinary retention. Palpitations, headache. Blurred vision, increased intraocular pressure. Muscular weakness. Rarely, blood dyscrasias e.g. agranulocytosis, haemolytic anaemia.
Mechanism of Action
Pheniramine is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.
Note
Expectryl Syrup manufactured by Sumy Pharmaceuticals Pvt. Ltd.. Its generic name is Pheniramine Maleate. Expectryl is availble in Nepal.
Farmaco Nepal drug index information on Expectryl Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.