Ezact 60 Tablet
Etoricoxib
60mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Ezact 60 Tablet is used for:
Rheumatoid arthritis, Osteoarthritis, Gout
Adult Dose
Oral
Osteoarthritis
Adult: 30 mg once daily, increased to 60 mg once daily if needed.
Ankylosing spondylitis; Rheumatoid arthritis
Adult: 90 mg once daily.
Acute gout
Adult: 120 mg once daily. Max duration: 8 days.
Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily.
Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily.
Severe (Child-Pugh >10): Avoid.
Child Dose
Child: <16 yr Contraindicated.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescent < 16 yr.
Precautions
Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with oedema due to other reasons; elderly, renal, cardiac or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.
Pregnancy-Lactation
Interactions
May increase INR w/ oral anticoagulants. May decrease effects of ACE inhibitors, angiotensin II antagonist and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.
Adverse Effects
Side effects of Etoricoxib :
GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.
Mechanism of Action
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.
Note
Ezact 60 60mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Etoricoxib. Ezact 60 is availble in Nepal.
Farmaco Nepal drug index information on Ezact 60 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.