Ezentia Tablet

Ezetimibe
10mg
Sun Pharmaceutical Industries Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 13.10 NPR

Indications

Ezentia Tablet is used for: Hyperlipidaemias, Homozygous familial sitosterolaemia, Hypercholesterolaemia

Adult Dose

Oral Hyperlipidaemias; Homozygous familial sitosterolaemia Adult: 10 mg once daily. Hepatic impairment Mild (Child-Pugh class A): Dose adjustment not necessary Moderate to severe (Child-Pugh class B or C): Not recommended

Child Dose

Child: >10 yr: 10 mg once daily.

Renal Dose

Renal impairment Monotherapy: No dosage adjustment required Moderate to severe: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity; moderate to severe liver disease or unexplained serum transaminase elevation. Children <10 yr, lactation.

Precautions

Renal or mild hepatic impairment. Monitor LFTs. Immediately discontinue ezetimibe and any HMG-CoA reductase inhibitor or fibrate if myopathy is diagnosed or suspected. Exclude or treat secondary causes of dyslipidaemia prior to initiating therapy. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Interactions

Reduced absorption w/ colestyramine. Increased plasma concentrations w/ ciclosporin. Concomitant use w/ oral anticoagulants may result in increased INR.

Adverse Effects

Side effects of Ezetimibe : 1-10% Diarrhea (4%),Upper respiratory tract symptoms (2-4%),Cough (2-4%),Pain in extremity (3%),Sinusitis (3%),Arthralgia (2-3%),Fatigue (2%),Influenza (2%),Increased liver transaminases (with HMG-CoA reductase inhibitors; >3 x ULN; 1%)

Mechanism of Action

Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, thus decreasing its delivery to the liver. This results in decrease in cholesterol stores within the liver and an increase in cholesterol clearance from the blood.

Note

Ezentia 10mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Ezetimibe. Ezentia is availble in Nepal. Farmaco Nepal drug index information on Ezentia Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Ezetimibe :