Famiclov Tablet

Famciclovir
Aadee Remedies Pvt. Ltd
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Indications

Famiclov Tablet is used for: Genital herpes, Herpes zoster, Herpes labialis, CMV infections, Mucocutaneous herpes

Adult Dose

Acute Herpes Zoster (Shingles) Treatment in immunocompetent adults 500 mg PO q8hr for 7 days; initiated within 72 hours of symptom or lesion onset Herpes Labialis Treatment of initial and recurrent episodes or suppressive therapy in immunocompetent adults Initial episode: 250 mg PO q8hr for 7-10 days Suppressive therapy: 250 mg PO q12hr for 12 months Recurrent episodes: 1500 mg PO once; initiate therapy at first sign (within 1 hour) of symptoms such as tingling, itching or burning Genital Herpes Treatment of initial and recurrent episodes or suppressive therapy in immunocompetent adults Initial episode: 250 mg PO q8hr for 7-10 days Suppressive therapy: 250 mg PO q12hr for up to 12 months Recurrent episodes: 1000 mg PO q12hr for 1 day; initiated within 6 hours of symptom or lesion onset Herpes (HIV-Infected Adults) Prevention of herpes simplex virus (HSV) reactivation and treatment of recurrent episodes Prevention of HSV reactivation: 500 mg PO q12hr Recurrent episodes: 500 mg PO q12hr for 5-10 days; initiated within 48 hours of symptom or lesion onset

Child Dose

Renal Dose

Acute herpes zoster CrCl >60 mL/min: Regular dosage CrCl 40-59 mL/min: 500 mg q12hr CrCl 20-39 mL/min: 500 mg once daily CrCl <20 mL/min: 250 mg once daily Hemodialysis: 250 mg after each session Herpes labialis CrCl >60 mL/min: Regular dosage CrCl 40-59 mL/min: 750 mg once CrCl 20-39 mL/min: 500 mg once CrCl <20 mL/min: 250 mg once Hemodialysis: 250 mg once after dialysis Genital herpes (treatment of recurrent disease) CrCl >60 mL/min: Regular dosage CrCl 40-59 mL/min: 500 mg q12hr for 1 day (2 doses total) CrCl 20-39 mL/min: 500 mg once CrCl <20 mL/min: 250 mg once Hemodialysis: 250 mg once after dialysis Genital herpes (suppressive therapy) CrCl >40 mL/min: Regular dosage CrCl 20-39 mL/min: 125 mg q12hr CrCl <20 mL/min: 125 mg/day Hemodialysis: 125 mg after each session Herpes (HIV-infected adults) CrCl >40 mL/min: Regular dosage CrCl 20-39 mL/min: 500 mg/day CrCl <20 mL/min: 250 mg/day Hemodialysis: 250 mg after each session

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity. Lactation.

Precautions

Renal impairment. Pregnancy. Lactation: Unknown whether drug is excreted in breast milk; caution advised

Pregnancy-Lactation

Interactions

Reduced renal excretion resulting to increased plasma concentration w/ probenecid. Raloxifen may reduce the formation of penciclovir, the active metabolite of famciclovir.

Adverse Effects

Side effects of Famciclovir : >10% Headache (23%),Nausea (13%) 1-10% Diarrhea (2-9%),Abdominal pain (8%),Dysmenorrhea (<8%),Vomiting (1-5%),Flatulence (5%),Pruritus (4%),Rash (3%),Paresthesia (3%),Neutropenia (3%),Increased transaminases (2-3%),Increased bilirubin (2%),Fatigue (1%) <1% Arthralgia,Confusion,Dizziness,Erythema multiforme,Hallucinations,Jaundice,Rigors,Thrombocytopenia,Upper respiratory tract infection

Mechanism of Action

Famciclovir rapidly undergoes biotransformation to penciclovir, which has inhibitory activity against HSV types 1 (HSV-1) and 2 (HSV-2) varicella-zoster virus (VZV). Thymidine kinase then phosphorylates penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This inhibits HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus inhibiting herpes viral DNA synthesis and replication.

Note

Famiclov Tablet manufactured by Aadee Remedies Pvt. Ltd. Its generic name is Famciclovir. Famiclov is availble in Nepal. Farmaco Nepal drug index information on Famiclov Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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