Fortwin Injection
Pentazocine Hydrochloride
Sun Pharmaceutical Industries Ltd.
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| Retail Price | 6.95 NPR |
Indications
Fortwin Injection is used for:
Moderate to severe pain
Adult Dose
Oral
Moderate to severe pain
Adult: 50-100 mg every 3-4 hrs; max 600 mg daily.
Hepatic impairment: Reduce dose or avoid in liver disease.
Child Dose
Oral
Moderate to severe pain
Child: 6-12 yr: 25 mg every 3-4 hr.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-50 75% normal dose.
<10 50% normal dose.
Administration
Should be taken with food. Take after meals.
Contra Indications
Head injury; narcotic dependence; respiratory depression; raised intracranial pressure; MI; heart failure; arterial or pulmonary hypertension; porphyria; pregnancy (prolonged use or high doses at term).
Precautions
May precipitate withdrawal in narcotic addicts. Impaired respiratory, renal and hepatic function; morbidly obese patients; thyroid dysfunction; prostatic hyperplasia or urinary stricture; biliary tract impairment; adrenal insufficiency (including Addison's disease); abdominal conditions. Elderly or debilitated patients; seizure-prone patients; children and infants (safety and efficacy not established in <1 yr); lactation. May impair ability to drive or operate machinery. Administer IM rather than SC (when frequent inj are needed) and inj sites should be varied.
Lactation: unknown if excreted in breast milk, use caution
Pregnancy-Lactation
Pregnancy Category: C; D if used for prolonged periods or near term
Interactions
Depressant affects potentiated by alcohol, CNS depressants; concurrent use with fluoxetine may lead to diaphoresis, ataxia flushing and tremor associated with serotonin syndrome.
Adverse Effects
Side effects of Pentazocine Hydrochloride :
Physical dependence; sedation, dizziness, euphoria, lightheadedness, alterations of mood; respiratory depression; visual hallucinations, disorientation, confusion; hypertension, tachycardia, circulatory depression; shock; hypotension; nausea, vomiting, constipation; seizures, diaphoresis; rash; blood dyscrasias; local tissue damages (SC), muscle fibrosis (IM).
Potentially Fatal: Respiratory depression, hypotension, circulatory failure, deepening coma, convulsions.
Mechanism of Action
Pentazocine is a benzomorphan derivative with mixed opioid agonist and antagonist actions. It alters perception of and response to pain and produces generalised CNS depression by binding to opiate receptors in the CNS and acting as a partial agonist/antagonist.
Note
Fortwin Injection manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Pentazocine Hydrochloride. Fortwin is availble in Nepal.
Farmaco Nepal drug index information on Fortwin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.