Fosamin Sachet
Fosfomycin
Beximco Pharmaceuticals Ltd.
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Indications
Fosamin Sachet is used for:
Urinary Tract Infection (Acute Cystitis), Acute uncomplicated urinary tract infections, Prostatitis
Adult Dose
Oral
Urinary Tract Infection (Acute Cystitis)
Acute cystitis caused by E. coli, E. faecalis
Women >18 years: 3 g PO once
Males >18 years: 3 g every 2-3 days for 3 doses
Prostatitis
3 g PO every 3 days for 21 days
Child Dose
Renal Dose
Renal impairment: No dosage adjustment needed.
Administration
Reconstitution: Oral powd: Dissolve the contents of a single-dose sachet containing 3 g of the drug in 90-120 mL of water. Do not use hot water.
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity to fosfomycin.
Precautions
Patient w/ cardiac insufficiency, HTN, hyperaldosteronism, hypernatraemia or pulmonary oedema. Renal impairment (IV). Pregnancy and lactation. Patient Counselling Certain adverse effects may occur which may impair ability to drive or operate machinery. Monitoring Parameters Monitor serum electrolyte levels and water balance; signs and symptoms of UTI.
Lactation: excreted in breast milk; not recommended
Pregnancy-Lactation
Interactions
Additive or synergistic effect w/ β-lactam antibiotics (e.g. penicillin, ampicillin, cefazolin, carbapenems) and anti-staphylococcal agents (e.g. linezolid, quinupristin/dalfopristin, moxifloxacin). Reduced serum levels w/ drugs which increase GI motility (e.g. metoclopramide).
Adverse Effects
Side effects of Fosfomycin :
1-10%
Anorexia,Diarrhea,Epigastric,Discomfort,Headache,Nausea,Rash,Vomiting
<1%
Dizziness,Drowsiness,Fatigue,Pruritus
Potentially Fatal: Anaphylactic shock, antibiotic-associated colitis and pseudomembranous colitis.
Mechanism of Action
Fosfomycin exerts bactericidal effect on proliferating pathogens by preventing the enzymatic synthesis of the bacterial cell wall. It inhibits the 1st stage of intracellular bacterial cell wall synthesis by blocking peptidoglycan synthesis.
Note
Fosamin Sachet manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Fosfomycin. Fosamin is availble in Nepal.
Farmaco Nepal drug index information on Fosamin Sachet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.