Frext 100 Tablet
Fluvoxamine Maleate
Intas Pharmaceuticals Ltd.
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| Retail Price | 383.04 NPR |
Available as:
Indications
Frext 100 Tablet is used for:
Major depressive disorder, Anxiety disorders, Depression, Panic disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder
Adult Dose
Oral
Obsessive compulsive disorder
Adult: 50 mg once daily; may increase by 50 mg every 4-7 days. Daily doses >100 mg should be given in 2 divided doses. Max: 300 mg daily.
Elderly: Initial 25mg once daily.
Depression
Adult: Initially, 50-100 mg daily, may increase gradually up to 300 mg daily, if necessary. Doses >150 mg should be given in 2 or 3 divided doses.
Hepatic impairment: Decrease dose
Child Dose
Oral
Obsessive compulsive disorder
Child: >8 yr: 25 mg once daily, may increase by 25 mg every 4-7 days. Doses >50 mg should be given in 2 divided doses.
Reassess if no improvement after 10 wk of treatment. Max: 200 mg daily.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Not to be used with thioridazine, terfenadine, astemizole, cisapride, pimozide, aloestron, tizanidine. Lactation.
Precautions
History of mania or seizures; liver dysfunction; presence of depressive symptoms; smokers. Treatment with MAOI should only be started at least 2 wk after stopping fluvoxamine treatment. Increased risk of suicidal ideation and behaviour when used in children, adolescents and young adults <24 yr. Pregnancy, elderly; operating hazardous machinery; withdraw gradually. Monitor prothrombin time in patients who are taking oral anticoagulants concurrently.
Lactation
Present in breast milk; avoid
Pregnancy-Lactation
Interactions
Co-admin with fluvoxamine may increase carbamazepine toxicity and serum levels of theophylline. Lithium enhances the serotonergic effects of fluvoxamine. Anticoagulants may require dosage adjustments. Diltiazem with fluvoxamine may lead to bradycardia. Avoid alcohol.
Potentially Fatal: Fluvoxamine should not be used in combination with MAOIs, or within 14 days of discontinuing treatment with MAOIs.
Adverse Effects
Side effects of Fluvoxamine Maleate :
>10%
Nausea (40%),Headache (22-35%),Somnolence (22-27%),Weakness (14-26%),Insomnia (20-35%),Diarrhea (11-18%),Dizziness (11-15%),Xerostomia (10-14%),Anorexia (6-14%),Abnormal ejaculation (8-11%)
1-10%
Pain (10%),Dyspepsia (8-10%),Constipation (4-10%),Decreased libido (2-10%),Upper respiratory infections (9%),Anxiety (5-8%),Tremor (5-8%),Sweating (6-7%),Vomiting (4-6%),Abdominal pain (5%),Myalgia (5%),Abnormal taste (2-5%),Bruising (4%),Abnormal dreams (3%),Abnormal thinking (3%),Chest pain (3%),Palpitation (3%),Agitation (2-3%),Vasodilation (2-3%),Hypertension (1-2%),Increased LFTs (1-2%),Weight change (1-2%),Manic reaction
<1%
Activation of mania/hypomania, seizures (discontinue),Sinusitis
Frequency Not Defined
Edema,Amnesia,Apathy,Asthenia,Malaise,Nervousness,Dry mouth,Myoclonus,Cough
Mechanism of Action
Fluvoxamine, derived from aralkylketone, inhibits the re-uptake of serotonin in brain neurons.
Note
Frext 100 Tablet manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Fluvoxamine Maleate. Frext 100 is availble in Nepal.
Farmaco Nepal drug index information on Frext 100 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.