Gdcip TZ Tablet
Ciprofloxacin + Tinidazole
500mg + 600mg
G.D. Laboratories Pvt. Ltd.
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Indications
Gdcip TZ Tablet is used for:
Gynaecological infections, Intra-abdominal infections, Respiratory tract infections, Prophylaxis of surgical infections
Adult Dose
Oral
Gynaecological infections, Intra-abdominal infections, Respiratory tract infections, Prophylaxis of surgical infections
Adult: As tablet containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300.
Usually 1 tablet bid for 5-10 days depending on severity and response.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity, patients with a history of blood dyscrasias.
Precautions
Renal impairment, history of seizures; ensure adequate hydration & urinary output; avoid alcohol ingestion. Not recommended for use in lactation and pregnancy. Not recommended for children. Patients with CNS disorders. Inadequate water intake during treatment may cause crystalluria.
Pregnancy-Lactation
Interactions
Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.
Adverse Effects
Side effects of Ciprofloxacin + Tinidazole :
Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes.
Potentially Fatal: Severe hypersensitivity reaction (rarely).
Mechanism of Action
Ciprofloxacin is bactericidal against enteropathogens like Shigella, Salmonella, E coli, C jejuni, Vibrio cholerae etc.It acts by inhibition of DNA synthesis. Tinidazole is a potent anaerobicide. It is also effective against Entameba & Giardia. It acts by damaging DNA strands. This combination has the advantage of being effective against both bacteria & protozoa. Entameba requires normal faecal flora for its survival; ciprofloxacin kills the pathogenic intestinal bacteria & alters intestinal flora, & tinidazole directly eradicates Entameba. This combination can also be used in other systemic infections caused by susceptible organisms.
Note
Gdcip TZ 500mg + 600mg Tablet manufactured by G.D. Laboratories Pvt. Ltd.. Its generic name is Ciprofloxacin + Tinidazole. Gdcip TZ is availble in Nepal.
Farmaco Nepal drug index information on Gdcip TZ Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.