Glanvec Injection

Vecuronium Bromide
10mg
Gland Pharma Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 332.00 NPR

Available as:

Indications

Glanvec Injection is used for: General anaesthesia, Skeletal muscle relaxation

Adult Dose

Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care Adult: Initially, 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min. Surgical procedures after intubation w/ suxamethonium: 30-50 mcg/kg. Caesarean section: <100 mcg/kg. Surgery under halothane and neurolept anaesth: Initially, 150-300 mcg/kg.

Child Dose

Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation; Facilitate mechanical ventilation in intensive care Child: <4 mth Initial test dose: 10-20 mcg/kg, w/ increments according to response; > 4 month: 80-100 mcg/kg by inj. Maintenance: 20-30 mcg/kg by inj or as continuous infusion at 0.8-1.4 mcg/kg/min. Neonatal surgery: <100 mcg/kg.

Renal Dose

Administration

Contra Indications

Hypersensitivity to vecuronium or bromide.

Precautions

Patient w/ CV disease, oedema, neuromuscular disease, previous poliomyelitis, burn injury, severe electrolyte disturbances, altered blood pH, dehydration; obese patient. Hepatic and renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BP, heart rate; peripheral nerve stimulation.

Pregnancy-Lactation

Interactions

Increases neuromuscular blockade with volatile anaesthetic agents (halothane, ether, enflurane, isoflurane, methoxyflurane, propofol and cyclopropane), fentanyl, other non-depolarising muscle relaxants, prior admin of succinylcholine, tetracyclines, polymyxins, diuretics, thiamine, MAOIs, bacitracin, colistin, sodium colistimethate, acylaminopenicillins, aminoglycoside antibiotics, high dose metronidazole, protamine, beta-adrenergic blocking agents, calcium antagonists e.g. verapamil, and Mg. Decreased neuromuscular blockade with anticholinesterases, prior chronic admin of corticosteroids, phenytoin, carbamazepine, noradrenaline, azathioprine, theophylline, calcium chloride.

Adverse Effects

Side effects of Vecuronium Bromide : Skeletal muscle weakness or paralysis, resp insufficiency or apnoea, bronchospasm, hypotension, tachycardia, acute urticaria, erythema, minimal induration, redness, itching, CV effects (e.g. changes in heart rate, cardiac index), myopathy. Potentially Fatal: Anaphylaxis.

Mechanism of Action

Vecuronium bromide inhibits depolarisation by blocking acetylcholine from binding to receptors on motor endplate.

Note

Glanvec 10mg Injection manufactured by Gland Pharma Pvt. Ltd.. Its generic name is Vecuronium Bromide. Glanvec is availble in Nepal. Farmaco Nepal drug index information on Glanvec Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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