Hemoff Injection
Tranexamic Acid
500mg
Acme Laboratories Ltd
| Pack size | 60AMP |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 75.00 NPR |
Available as:
Indications
Hemoff Injection is used for:
Haemorrhage, Hereditary angioedema
Adult Dose
Oral
Short-term management of haemorrhage
Adult: 1-1.5 g or 15-25 mg/kg bid or tid.
Management of hereditary angioedema
Adult: 1-1.5 g bid or tid.
Intravenous
Short-term management of haemorrhage
Adult: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.
Child Dose
Oral
Short-term management of haemorrhage
Child: 25 mg/kg bid or tid.
Management of hereditary angioedema
Child: 25 mg/kg bid or tid.
Intravenous
Short-term management of haemorrhage
Child: 10 mg/kg bid or tid.
Renal Dose
Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr.
Administration
May be taken with or without food.
Contra Indications
Severe renal failure, active intravascular clotting, thromboembolic disease, colour vision disorders, subarachnoid bleeding.
Precautions
Mild to moderate renal impairment, irregular menstrual bleeding, previous history of thromboembolic disease, haematuria. Monitor closely in disseminated intravascular coagulation. Monitor LFT and eye examination regularly during long-term use. Discontinue if disturbance in colour vision occurs. Avoid IV inj rate >1 ml/minute due to risk of hypotension. Pregnancy, lactation.
Pregnancy-Lactation
Interactions
Potentially Fatal: Increased risk of thrombus formation with estrogens, Factor IX complex concentrates or anti-inhibitor coagulant concentrates. Increased risk of fatal thrombotic complications with tretinoin in acute promyelocytic leukaemia.
Adverse Effects
Side effects of Tranexamic Acid :
>10%
Headache (50.4%),Nasal and sinus symptoms (25.4%),Back pain (20.7%),Abdominal pain (19.8%),Musculoskeletal pain (11.2%)
1-10%
Arthralgia (6.9%),Muscle cramps and spasms (5.8%),Migraine (6%),Anemia (5.6%),Fatigue (5.2%)
Frequency Not Defined
Visual abnormalities,Hypotension (with rapid injection),Nausea,Vomiting,Diarrhea
Mechanism of Action
Tranexamic acid is an antifibrinolytic agent that competitively inhibits breakdown of fibrin clots. It blocks binding of plasminogen and plasmin to fibrin, thereby preventing haemostatic plug dissolution.
Note
Hemoff 500mg Injection manufactured by Acme Laboratories Ltd. Its generic name is Tranexamic Acid. Hemoff is availble in Nepal.
Farmaco Nepal drug index information on Hemoff Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.