Hetrazan Tablet
Diethylcarbamazine Citrate
100mg
Pfizer Ltd.
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| Retail Price | 2.12 NPR |
Indications
Hetrazan Tablet is used for:
Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis
Adult Dose
W. Bancrofti, B Malayi
Day 1: 50 mg PO PC
Day 2: 50 mg TID
Day 3: 100 mg TID
Day 4-14: 6 mg/kg/day divided TID
Loa Loa
Day 1: 50 mg PO PC
Day 2: 50 mg TID
Day 3: 100 mg TID
Day 4-21: 9 mg/kg/day divided TID
M. Streptocerca
6 mg/kg PO qDay x14 days
Pulmonary Eosinophilia, Tropical
Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days
Larva Migrans, Visceral
6 mg/kg/day divided TID x7-10 days
Child Dose
W. Bancrofti, B Malayi
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TID
Day 3: 1-2 mg/kg PO TID
Day 4-14: 6 mg/kg/day divided TID
Loa Loa
Day 1: 1 mg/kg PO PC
Day 2: 1 mg/kg PO TID
Day 3: 1-2 mg/kg PO TID
Day 4-21: 9 mg/kg/day divided TID
Pulmonary Eosinophilia, Tropical
Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days
Larva Migrans, Visceral
6 mg/kg/day divided TID x7-10 days
Renal Dose
Administration
Contra Indications
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.
Precautions
Patients with poor health.
Lactation: not known if excreted in breast milk
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diethylcarbamazine Citrate :
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.
Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.
Mechanism of Action
Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary.
Note
Hetrazan 100mg Tablet manufactured by Pfizer Ltd.. Its generic name is Diethylcarbamazine Citrate. Hetrazan is availble in Nepal.
Farmaco Nepal drug index information on Hetrazan Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.