Humalog Mix 50 Kwikpen
Insulin Lispro (25%/50%) + Insulin Lispro Protamine (75%/50%) mix
Eli Lilly And Company India Pvt Ltd
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Available as:
Indications
Humalog Mix 50 Kwikpen is used for:
Diabetes mellitus
Adult Dose
Subcutaneous
Diabetes Mellitus
Combination rapid-onset (faster than regular insulin) and intermediate-acting insulins in fixed dose
Dose regimen varies among patients depending on metabolic needs; typical daily insulin requirements range between 0.5-1 unit/kg
Initially, 10 units with the largest meal of the day, dose adjustments may be made on a wkly basis according to blood glucose levels.
Dose should not be increased if there is hypoglycaemic episode (<70 mg/dl) during a 3-day period.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Dose adjustments may be required.
Administration
Administer SC BID (ie, before breakfast and evening meal); each dose intended to cover 2 meals or a meal and snack
Inject SC into abdominal wall, thigh, or upper arm
Contra Indications
Hypoglycaemia. Hypersensitivity to any of the components.
Precautions
Renal or hepatic impairment; pregnancy, lactation; transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections.
Lactation: Unknown whether distributed in breast milk; compatible with breast feeding, but lactating women may require dosage adjustment; caution advised
Pregnancy-Lactation
Interactions
Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by beta-blockers, clonidine.
Adverse Effects
Side effects of Insulin Lispro (25%/50%) + Insulin Lispro Protamine (75%/50%) mix :
Hypoglycaemia; hypokalemia, oedema; pruritus; pulpitation, nausea, rash; hypersensitivity reactions; lipoatropy or lipohypertrophy with SC Inj.
Mechanism of Action
Insulin lispro is a short-acting biosynthetic human insulin analogue. Insulin lispro protamine is an intermediate-acting glucose-lowering agent; it is a suspension of crystals produced from combining insulin lispro and protamine sulfate under appropriate conditions for crystal formation. They are used together for the regulation of glucose metabolism.
Note
Humalog Mix 50 Kwikpen manufactured by Eli Lilly And Company India Pvt Ltd. Its generic name is Insulin Lispro (25%/50%) + Insulin Lispro Protamine (75%/50%) mix. Humalog Mix 50 is availble in Nepal.
Farmaco Nepal drug index information on Humalog Mix 50 Kwikpen is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.