Hyvisc Plus Injection
Sodium Hyaluronate
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Hyvisc Plus Injection is used for:
Osteoarthritis
Adult Dose
Intra-articular
Adult:
Osteoarthritis of Knee
Indicated for treatment of pain in osteoarthritis of the knee
Inject 20 mg (2 mL) once wkly for 3-5 weeks.
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Hypersensitivity to sodium hyaluronate or avian proteins. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.
Precautions
Use caution when injecting Sodium Hyaluronate into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Sodium Hyaluronate. Do not use the same syringe for removing joint effusion and for injecting Sodium Hyaluronate. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.
Pregnancy-Lactation
Interactions
The safety and effectiveness of the use of sodium hyaluronate concomitantly with other intra-articular injection has not yet been established.
As sodium hyaluronate is precipitated by quaternary amine bactericides or disinfectants eg, benzalkonium chloride and chlorhexidine, etc, adequate attention should be given.
Adverse Effects
Side effects of Sodium Hyaluronate :
Intra-articular inj: Pain and inflammation at inj site. Hypersensitivity; anaphylaxis; hypotensive crisis.
The common side-effects include gastrointestinal complaints, knee swelling/effusion, local skin reactions (rash, ecchymosis), pruritus, and headache.
Mechanism of Action
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.
Note
Hyvisc Plus Injection manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Sodium Hyaluronate. Hyvisc Plus is availble in Nepal.
Farmaco Nepal drug index information on Hyvisc Plus Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.