I-Dox Injection
Doxorubicin + Pegylated Liposomal
20mg/ml
Getwell Pharmaceuticals
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Indications
I-Dox Injection is used for:
Kaposi's Sarcoma, Ovarian Cancer, Multiple Myeloma
Adult Dose
Kaposi's Sarcoma
Indicated for AIDS-related Kaposi’s sarcoma in patients after failure of prior systemic chemotherapy or intolerance to such therapy
20 mg/m² IV q3Weeks
Ovarian Cancer
Indicated for ovarian cancer in patients whose disease has progressed or recurred after platinum-based chemotherapy
50 mg/m² IV q4Weeks x 4 courses minimum
Multiple Myeloma
Indicated in combination with bortezomib for multiple myeloma in patients who have not previously received bortezomib and have received at least 1 prior therapy
30 mg/m² IV on day 4 following bortezomib 1.3 mg/m² on days 1, 4, 8 & 11 q3Weeks
Hepatic impairment: Reduce dose if serum bilirubin >1.2 mg/dL
Child Dose
Renal Dose
Administration
IV Preparation
Dilute aseptically <90 mg doses in 250 mL & >90 mg doses in 500 mL D5W (do NOT use other IV fluids)
Refrigerate at 2-8°C & administer within 24 hr
Red translucent dispersion (will not be a clear solution)
IV Administration
Initial infusion at 1 mg/min, if no infusion reaction may increase rate to complete infusion in 1 hr
Do not administer as bolus injection or undiluted suspension
Do not use in-line filter
Use cytotoxic precautions for handling, administration, and disposal
Contra Indications
Hypersensitivity. AIDS-KS that may be effectively treated w/ local therapy or systemic α-interferon. Pregnancy & lactation.
Precautions
History of CV disease, impaired cardiac function, patients who have received other anthracyclines. Perform periodic blood counts. Caution when administered w/ other cytotoxic agents especially myelotoxic agents.
Pregnancy-Lactation
Interactions
May exacerbate cyclophosphamide-induced hemorrhagic cystitis & enhance the hepatotoxicity of 6-mercaptopurine.
Adverse Effects
Side effects of Doxorubicin + Pegylated Liposomal :
Leukopenia, anemia, thrombocytopenia; nausea, asthenia, alopecia, fever, diarrhea, infusion-associated acute reactions, stomatitis. Less frequently, palmar-plantar erythrodyesthesia.
Mechanism of Action
Anthracycline; intercalates between DNA base pairs, impairs topoisomerase II function and subsequently inhibits DNA and RNA replication
Doxorubicin is a strong chelator; doxorubicin-iron complex binds to cell membranes and DNA and produces free hydroxyl radicals that cleaves them
Note
I-Dox 20mg/ml Injection manufactured by Getwell Pharmaceuticals. Its generic name is Doxorubicin + Pegylated Liposomal. I-Dox is availble in Nepal.
Farmaco Nepal drug index information on I-Dox Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.