I-Mix Tablet
Cefixime
200mg
Sumy Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
I-Mix Tablet is used for:
Pneumonia, Pharyngitis, Typhoid fever, Susceptible infections , Sinusitis, Otitis media, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Gonococcal urethritis, Acute bronchitis
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections
Adult: 200 or 400 mg daily as a single dose or in two divided doses
Gonorrhea: 400 mg as a single dose.
Typhoid fever: 20 mg/kg body weight daily in two divided dose.
The usual treatment of is 7 days.
This may be continued for up to 14 days according to the severity of infection.
Child Dose
Child: PO 8 mg/kg/day if <50 kg q12–24h
For convalescent oral therapy of serious infections, up to 20 mg/kg/day
Powder for Suspension & DS Powder for Suspension:
Children above 6 months: 8 mg/kg daily in 1-2 divided doses or
6 months-1year: 75 mg daily
1-4 years: 100 mg daily
5-10 years: 200 mg daily
Typhoid Fever
15-20 mg/kg/day PO divided q12hr for 7-14 days; not to exceed 400 mg/day
<6 months: Safety and efficacy not established
Renal Dose
Renal impairment: Dose reduction is necessary.
CrCl (ml/min)
<20 Max: 200 mg daily.
Administration
May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.
Contra Indications
Hypersensitivity to cephalosporin.
Precautions
History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.
Lactation: Unknown whether drug is excreted in milk
Pregnancy-Lactation
Interactions
Increased concentrations with probenecid.
Potentially Fatal: May increase prothrombin time with anticoagulants.
Adverse Effects
Side effects of Cefixime :
>10%
Diarrhea (16%)
Frequency Not Defined
Abdominal pain,Candidiasis,Dizziness,Dyspepsia,Elevated transaminases,Eosinophilia,Erythema multiforme,Fever,Flatulence,Headache,Increased blood urea nitrogen (BUN),Increased creatinine,Leukopenia,Nausea,Prolonged prothrombin time (PT),Pruritus,Pseudomembranous colitis,Rash,Serum sickness-like reaction,Stevens-Johnson syndrome,Thrombocytopenia,Urticaria,Vaginitis,Vomiting
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
I-Mix 200mg Tablet manufactured by Sumy Pharmaceuticals Pvt. Ltd.. Its generic name is Cefixime. I-Mix is availble in Nepal.
Farmaco Nepal drug index information on I-Mix Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.