Indications
Iclenac SR Tablet is used for:
Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis;
Adult Dose
Adult: PO Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis
100 mg twice daily.
SR Tablet : The recommended dose is 200 mg, once daily.
Injection
The recommended dose is 150 mg once or twice daily for 5 days or as recommended by the physician.
Gel: Topical gel used thinly twice daily or as directedby the physician.
Hepatic Impairment Reduce initial dose to 100 mg daily .
Child Dose
Renal Dose
Administration
Should be taken with food. Take w/ or immediately after meals.
Contra Indications
Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.
Precautions
Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly.
Pregnancy-Lactation
Interactions
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
Adverse Effects
Side effects of Aceclofenac :
Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs.
Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.
Mechanism of Action
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Note
Iclenac SR 200mg Tablet manufactured by Umedica. Its generic name is Aceclofenac. Iclenac SR is availble in Nepal.
Farmaco Nepal drug index information on Iclenac SR Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.