Iibrium 25 Tablet
Chlordiazepoxide
25mg
Abbott India Ltd.
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Available as:
Indications
Iibrium 25 Tablet is used for:
Anxiety, Insomnia, Muscle spasms, Acute symptoms of alcohol withdrawal
Adult Dose
Oral
Insomnia
Adult: 10-30 mg before bedtime.
Muscle spasms
Adult: 10-30 mg daily in divided doses.
Anxiety
Adult: 30 mg daily in divided doses, up to 100 mg daily in severe conditions.
Acute symptoms of alcohol withdrawal
Adult: 25-100 mg daily repeated as necessary. Max dose: 300 mg daily.
Elderly: and debilitated patients: Dose reduction may be needed.
Child Dose
Anxiety
<6 years: Safety and efficacy not established
>6 years: 0.5 mg/kg/day divided PO q6-8hr,
OR 5 mg PO q6-12hr; may increase dose to 10 mg PO q8-12hr
Renal Dose
Renal impairment
CrCl <10 mL/min: 50% of recommended dose
CrCl >10 mL/min: Dose adjustment not necessary (monitor)
Administration
May be taken with or without food.
Contra Indications
Acute pulmonary insufficiency, resp depression, patients with marked neuromuscular resp weakness; hypersensitivity to benzodiazepines; chronic psychosis; porphyria; pregnancy and lactation.
Precautions
Alcohol; sedation, dependence. Elderly and debilitated patients. Liver or kidney dysfunction. Avoid prolonged usage.
Lactation: Enters breast milk/not recommended
Pregnancy-Lactation
Interactions
Cimetidine increases serum conc of chlordiazepoxide. Potentiates action of major neuroleptics.
Potentially Fatal: Alcohol potentiates CNS-depressant effect of chlordiazepoxide.
Adverse Effects
Side effects of Chlordiazepoxide :
>10%
Ataxia,Drowsiness,Memory impairment,Sedation,Muscle weakness,Rash,Decreased libido,Menstrual disorders,Xerostomia,Salivation decreased,Increased/decreased appetite,Weight gain/loss,Micturition difficulties
1-10%
Confusion,Dizziness,Disinhibition,Akathisia,Dermatitis,Hypotension,Salivation increased,Sexual dysfunction,Incontinence,Rigidity,Tremor,Muscle cramps,Tinnitus,Nasal congestion
Mechanism of Action
Chlordiazepoxide enhances activity of the inhibitory transmitter GABA in different parts of CNS by increasing neuronal-membrane permeability to chloride ions resulting to hyperpolarisation and stabilisation. It has some muscle relaxant and anticonvulsant activity.
Note
Iibrium 25 25mg Tablet manufactured by Abbott India Ltd.. Its generic name is Chlordiazepoxide. Iibrium 25 is availble in Nepal.
Farmaco Nepal drug index information on Iibrium 25 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.