Instaryl Tablet
Salbutamol + Bromhexine
5mg + 4mg
Aglowmed Pharmaceuticals Ltd.
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Indications
Instaryl Tablet is used for:
Bronchial asthma, emphysema, atelectasis, acute/chronic bronchitis, pulmonary TB, whooping cough, pneumonia & other broncho-spastic conditons.
Adult Dose
Oral
Adult 2 tsf tid.
Child Dose
Oral
Childn 6-12 yr 1-2 tsf tid,
<6 yr 1 tsf tid.
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity
Precautions
Patients w/ hyperthyroidism, DM, serious CV disorders, HTN & peptic ulcer. Pregnancy & lactation.
Pregnancy-Lactation
Interactions
Diuretics, MAOIs, digoxin.
Adverse Effects
Side effects of Salbutamol + Bromhexine :
Skeletal muscle tremor of the hands, palpitations, muscle cramps. Slight tachycardia, headache & peripheral vasodilation at large doses.
Mechanism of Action
Salbutamol activates adenyl cyclase, the enzyme that stimulates the production of cyclic adenosine-3', 5'-monophosphate (cAMP). Increased cAMP leads to activation of protein kinase A, which inhibits phosphorylation of myosin and lowers intracellular ionic Ca concentrations, resulting in smooth muscle relaxation.
Bromhexine enhances mucus transport by reducing mucus viscosity and by activating the ciliated epithelium (mucociliary clearance).
Note
Instaryl 5mg + 4mg Tablet manufactured by Aglowmed Pharmaceuticals Ltd.. Its generic name is Salbutamol + Bromhexine. Instaryl is availble in Nepal.
Farmaco Nepal drug index information on Instaryl Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.