Ipcazide Syrup
Isoniazid + Pyridoxine
100mg + 5mg
Ipca Laboratories Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 35.68 NPR |
Indications
Ipcazide Syrup is used for:
Tuberculosis
Adult Dose
Oral
Tuberculosis
Adult: 5 mg/kg up to 300 mg daily as a single dose or 15 mg/kg up to 900 mg/day, 2 or 3 times wkly.
Child Dose
Oral
Tuberculosis
Child: 10-15 mg/kg up to 300 mg daily as a single dose or 20-40 mg/kg up to 900 mg/day, 2 or 3 times wkly.
Renal Dose
Renal impairment: Severe: Dose reduction may be needed.
Administration
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity. Patient w/ acute liver disease or a history of isoniazid-associated hepatic injury.
Precautions
Patient w/ convulsive disorders, history of psychosis. Patient at risk of neuropathy (e.g. diabetics, alcoholics, malnourished, uraemic, infected w/ HIV) or pyridoxine deficiency. Hepatic and severe renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor baseline and periodic LFTs (ALT and AST), sputum cultures mthly until 2 consecutive negative cultures reported and prodromal signs of hepatitis.
Lactation: distributed into milk but safe for nursing infants
Pregnancy-Lactation
Interactions
Inhibit the hepatic metabolism of antiepileptics (e.g. carbamazepine, ethosuximide, primidone, phenytoin), benzodiazepines (e.g. diazepam, triazolam), chlorzoxazone, theophylline, disulfiram, sometimes leading to increased toxicity. Increased metabolism of enflurane, resulting in potentially nephrotoxic levels of fluoride. Increased concentrations and enhanced effects or toxicity of clofazimine, cycloserine and warfarin. Reduced absorption w/ Al-containing antacids. Increased risk of peripheral neuropathy w/ zalcitabine and stavudine.
Adverse Effects
Side effects of Isoniazid + Pyridoxine :
>10%
Mild incr LFTs (10-20%),Peripheral neuropathy (dose-related incidence, 10-20% incidence with 10 mg/kg/d),Loss of appetite,Nausea,Vomiting,Stomach pain,Weakness
1-10%
Dizziness,Slurred speech,Lethargy,Progressive liver damage (increases with age; 2.3% in pts > 50 yo),Hyperreflexia
<1%
Agranulocytosis,Anemia,Megaloblastic anemia,Thrombocytopenia,Systemic lupus erythematosus,Seizure
Mechanism of Action
Isoniazid inhibits the synthesis of mycoloic acids in susceptible bacteria which results in loss of acid-fastness and disruption of bacterial cell wall. At therapeutic levels, it is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.
Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Note
Ipcazide 100mg + 5mg Syrup manufactured by Ipca Laboratories Ltd.. Its generic name is Isoniazid + Pyridoxine. Ipcazide is availble in Nepal.
Farmaco Nepal drug index information on Ipcazide Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.