Irovel H Tablet
Hydrochlorothiazide + Irbesartan
12.5mg + 150mg
Sun Pharmaceutical Industries Ltd.
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| Retail Price | 18.24 NPR |
Indications
Irovel H Tablet is used for:
Diabetic nephropathy, Hypertension
Adult Dose
Hypertension
150 mg/12.5 mg PO qDay intially; if needed, after 1-2 weeks may titrate up to 300 mg/25 mg PO qDay
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; pregnancy and lactation.
Precautions
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
Lactation: discontinue drug or do not nurse
Pregnancy-Lactation
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)
Interactions
Other antihypertensives, lithium, K-sparing diuretics, K supplements, salt substitutes containing K. CNS depressants, antidiabetics, cholestyramine & colestipol resins, corticosteroids, ACTH, digitalis glycosides, antiarrhythmics, NSAIDs, tubocurarine, antigout medications, Ca salts. Alcohol; ?-blockers, diazoxide, atropine, beperiden, amantadine, cyclophosphamide, methotrexate.
Adverse Effects
Side effects of Hydrochlorothiazide + Irbesartan :
>10%
Irbesartan
Hyperkalemia (19%)
1-10%
Chest pain (2%),Tachycardia (1%),Abnormal urination (2%),Musculoskeletal pain (6%),Flu-like syndrome (3%),Edema (3%),Tachycardia (1%),Chest pain (2%),Creatinine increased (1%),Increased BUN (2%)
Irbesartan
Dizziness (10%),URI (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%)
Frequency Not Defined
Hydrochlorothiazide
Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia,Headache
Mechanism of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
Note
Irovel H 12.5mg + 150mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Hydrochlorothiazide + Irbesartan. Irovel H is availble in Nepal.
Farmaco Nepal drug index information on Irovel H Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.