Kabimol Injection
Paracetamol IV
100ml
Fresenius Kabi pharmaceuticals
| Pack size | 1's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 497.96 NPR |
Indications
Kabimol Injection is used for:
Mild to moderate pain and high fever
Adult Dose
Intravenous
Mild to moderate pain and fever
Adult >50 kg: 1g up to 4 times a day. Max: 4 g daily. Admin by infusion over 15 min.
Adult 33 to 50 kg: 15 mg/kg body wt, up to 4 times a day. Max: 60 mg/kg (up to 3 g) daily
Child Dose
Intravenous
Mild to moderate pain and fever
Child >12 years, >50 kg: 1g up to 4 times a day. Max: 4 g daily. Admin by infusion over 15 min.
Child 2-12 years: upto 33kg: 15 mg/kg body wt, up to 4 times a day. Max: 75 mg/kg daily.
Children: <10 kg: 7.5 mg/kg body wt, up to 4 times a day.
Renal Dose
Administration
The paracetamol solution is administered as a 15-minutes intravenous infusion. Paracetamol solution for infusion can be diluted in a 0.9% Sodium Chloride or 5% Glucose solution up to one tenth. In this case, use the diluted solution within the hour following its preparation (infusion time included).
Contra Indications
Paracetamol is contraindicated in patients with severe renal impairment and hepatic disease (Viral Hepatitis). Known hypersensitivity to paracetamol.
Precautions
Hepatocelluar insufficiency. Severe renal insufficiency (creatinine clearance <30 mL/min), Glucose-6-Phosphate Dehyrogenase (G6PD) deficiency, Chronic alcoholism, Anorexia, cachexia, chronic malnutrition, Dehydration, hypovolemia.
Pregnancy-Lactation
Interactions
Hepatotoxic drugs, liver microsomal enzyme inducers. Metoclopramide. Probenecid. Colestyramine (w/in 1 hr of paracetamol administration).
Adverse Effects
Side effects of Paracetamol IV :
Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Mechanism of Action
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Note
Kabimol 100ml Injection manufactured by Fresenius Kabi pharmaceuticals. Its generic name is Paracetamol IV. Kabimol is availble in Nepal.
Farmaco Nepal drug index information on Kabimol Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.