Kaftus Syrup

Dextromethorphan + Chlorpheniramine + Phenylephrine
7.5mg + 2.5mg + 7.5mg
Sumy Pharmaceuticals Pvt. Ltd.
Pack size 50ml
Dispensing mode
Source
Agent
Retail Price 50.00 NPR

Indications

Kaftus Syrup is used for: Relief of Cough Associated with Allergies or the Common Cold

Adult Dose

Oral Temporary Relief of Cough Associated with Allergies or the Common Cold Syrup 30 mL [(2mg/5mg/5mg)/15mL] PO q4hr; not to exceed 180 mL/day 5 mL [(2-4mg/15mg/5-10mg)/5mL] PO q4-6hr; not to exceed 20 mL/day Tablet 1 tab PO q4-6hr; not to exceed 6 tab/24hr

Child Dose

Oral Temporary Relief of Cough Associated with Allergies or the Common Cold Syrup 6-12 Years Old 2 mL [(0.75mg/2.75mg/1.75mg)/1mL] PO q4-6hr; not to exceed 12 mL/day 2 mL [(1mg/2.5-3mg/2-2.5mg)/1mL] PO q4-6hr; not to exceed 8 mL/day 1 mL [(1mg/3mg/3.5mg)/1mL] PO q4-6hr; not to exceed 6 mL/day 2.5mL [(2-4mg/15mg/5-10mg)/5mL PO q4-6hr; not to exceed 15mL/day Tablet 1/2 tab PO q4-6hr; not to exceed 3 tabs/day >12 Years Old Syrup 30 mL [(2mg/5mg/5mg)/15mL] PO q4hr; not to exceed 180 mL/day 5 mL [(2-4mg/15mg/5-10mg)/5mL] PO q4-6hr; not to exceed 20 mL/day Tablet 1 tab PO q4-6hr; not to exceed 6 tab/24hr

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

Precautions

Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates Lactation: excretion in milk unknown/not recommended

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Dextromethorphan + Chlorpheniramine + Phenylephrine : Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Drowsiness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,GI disturbances,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia. Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.

Note

Kaftus 7.5mg + 2.5mg + 7.5mg Syrup manufactured by Sumy Pharmaceuticals Pvt. Ltd.. Its generic name is Dextromethorphan + Chlorpheniramine + Phenylephrine. Kaftus is availble in Nepal. Farmaco Nepal drug index information on Kaftus Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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