Kafxim D-SY

Cefixime
Mark Ltd.
Pack size 100ml
Dispensing mode
Source
Agent
Retail Price

Indications

Kafxim D-SY is used for: Pneumonia, Pharyngitis, Typhoid fever, Susceptible infections , Sinusitis, Otitis media, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Gonococcal urethritis, Acute bronchitis

Adult Dose

Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections Adult: 200 or 400 mg daily as a single dose or in two divided doses Gonorrhea: 400 mg as a single dose. Typhoid fever: 20 mg/kg body weight daily in two divided dose. The usual treatment of is 7 days. This may be continued for up to 14 days according to the severity of infection.

Child Dose

Child: PO 8 mg/kg/day if <50 kg q12–24h For convalescent oral therapy of serious infections, up to 20 mg/kg/day Powder for Suspension & DS Powder for Suspension: Children above 6 months: 8 mg/kg daily in 1-2 divided doses or 6 months-1year: 75 mg daily 1-4 years: 100 mg daily 5-10 years: 200 mg daily Typhoid Fever 15-20 mg/kg/day PO divided q12hr for 7-14 days; not to exceed 400 mg/day <6 months: Safety and efficacy not established

Renal Dose

Renal impairment: Dose reduction is necessary. CrCl (ml/min) <20 Max: 200 mg daily.

Administration

May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.

Contra Indications

Hypersensitivity to cephalosporin.

Precautions

History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease. Lactation: Unknown whether drug is excreted in milk

Pregnancy-Lactation

Interactions

Increased concentrations with probenecid. Potentially Fatal: May increase prothrombin time with anticoagulants.

Adverse Effects

Side effects of Cefixime : >10% Diarrhea (16%) Frequency Not Defined Abdominal pain,Candidiasis,Dizziness,Dyspepsia,Elevated transaminases,Eosinophilia,Erythema multiforme,Fever,Flatulence,Headache,Increased blood urea nitrogen (BUN),Increased creatinine,Leukopenia,Nausea,Prolonged prothrombin time (PT),Pruritus,Pseudomembranous colitis,Rash,Serum sickness-like reaction,Stevens-Johnson syndrome,Thrombocytopenia,Urticaria,Vaginitis,Vomiting Potentially Fatal: Pseudomembranous colitis.

Mechanism of Action

Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Note

Kafxim D-SY manufactured by Mark Ltd.. Its generic name is Cefixime. Kafxim is availble in Nepal. Farmaco Nepal drug index information on Kafxim D-SY is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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