Kancin Injection
Kanamycin
500mg
Alembic Pharmaceuticals Ltd.
| Pack size | 1 |
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Indications
Kancin Injection is used for:
Susceptible bacterial Infections
Adult Dose
Susceptible Infections
IV Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day divided q6-12hr; administer slowly
IM Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day IM divided q12hr at equally divided intervals; continuously high blood levels are desired; daily dose of 15 mg/kg may be given divided q6-8hr
Child Dose
Renal Dose
Renal Impairment
CrCl 50-80 mL/min: give 60-90% of usual dose or give q8-12hr
CrCl 10-50 mL/min: give 30-70% of usual dose or give q12hr
CrCl <10 mL/min: give 20-30% of usual dose or give q24-48hr
Administration
IV Preparation
For adults, IV infusions are prepared by adding 500 mg of kanamycin to 100-200 mL of usual IV infusion fluid such as NS or D5W or by adding 1 g of the drug to 200-400 mL of diluent
IV/IM Administration
Administer by deep IM injection, or IV infusion
May administer by intraperitoneal instillation, irrigation, or inhalation
Infuse over 30-60 min
Contra Indications
Hypersensitivity
Precautions
Auditory toxicity more common with kanamycin than with streptomycin and capreomycin; monthly audiometry is recommended while patients are being treated with this drug; vestibular toxicity is rare; renal toxicity occurs at a frequency similar to that of capreomycin; regular monitoring of serum creatinine recommended
Renal impairment
Myasthenia gravis
Vestibular/cochlear implant
Nephrotoxic agents
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Kanamycin :
Agranulocytosis,Anorexia,Diarrhea,Dyspnea,Edema,Elevated BUN,Enterocolitis,Headache,Incr salivation,Muscle cramps,Muscle weakness,Nausea,Nephrotoxicity,Neurotoxicity,Ototoxicity,Pruritus,Pseudotumor cerebri,Rash,Tinnitus,Thrombocytopenia,Tremor,Vertigo,Weakness
Mechanism of Action
Bactericidal
Aminoglycoside contain 1 or 2 amino sugars linked to an aminocyclitol nucleus. Nucleus is 2-deoxystreptamine. Bactericidal and believed to inhibit protein synthesis by binding to 30 S ribosomal subunit.
Note
Kancin 500mg Injection manufactured by Alembic Pharmaceuticals Ltd.. Its generic name is Kanamycin. Kancin is availble in Nepal.
Farmaco Nepal drug index information on Kancin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.