Karb A Tablet

Alphacalcidol + Calcium Carbonate
0.25MCG + 500MG
Nova Genetica Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 18.00 NPR

Indications

Karb A Tablet is used for: Postmenopausal osteoporosis, Osteoporosis, Osteomalacia/Rickets, Hypoparathyroidism, Latent tetany, Hypocalcaemia, Calcium and vitamin D deficiency, Renal osteodystrophy

Adult Dose

Adult: PO: 1 cap once/twice daily.

Child Dose

Renal Dose

Administration

Should be taken with food.

Contra Indications

Patients with hypercalcaemia and/or hypercalciuria. Nephrolithiasis, hypervitaminosis D, hypophosphataemia.

Precautions

Pregnancy, lactation, renal impairment, infants, elderly. Monitor serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi.

Pregnancy-Lactation

Interactions

May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Thiazides may increase the risk of hypercalcaemia. Some antiepileptics e.g. carbamazepine, phenobarbital, phenytoin and primidone may increase vitamin D requirements. Rifampicin, isoniazid and corticosteroids may reduce the efficacy of vitamin D.

Adverse Effects

Side effects of Alphacalcidol + Calcium Carbonate : Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia.

Mechanism of Action

Alfacalcidol is a precursor of the active calcitriol. It does not require renal hydroxylation but requires 25-hydroxylation in the liver for conversion to calcitriol.

Note

Karb A 0.25MCG + 500MG Tablet manufactured by Nova Genetica Pvt. Ltd.. Its generic name is Alphacalcidol + Calcium Carbonate. Karb A is availble in Nepal. Farmaco Nepal drug index information on Karb A Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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