Keftragard Injection

Ceftriaxone + Sulbactam
1000mg + 500mg
Ipca Laboratories Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 223.02 NPR

Indications

Keftragard Injection is used for: Treatment of lower resp tract infections; acute bacterial otitis media; skin & skin structure infections; UTI (complicated & uncomplicated); pelvic inflammatory disease; bone & joint infections; intra-abdominal infections; meningitis; resistant typhoid; STD; surgical prophylaxis; bacterial septicemia.

Adult Dose

Adult 1-2 g once daily (or in 2 divided doses). Max: 4 g/day. Uncomplicated gonococcal infections 250 mg IM as a single dose. Surgical prophylaxis 1 g IV single dose, ½-2 hr before surgery. Meningitis Initially 100 mg/kg/day. Max: 4 g/day. Duration: 7-14 days. Strep pyogenes infections Continue therapy for at least 10 days.

Child Dose

Childn Skin & skin structure infections Ceftriaxone 50-75 mg/kg once daily (or in equally divided doses). Max: 2 g/day. Acute bacterial otitis media 50 mg/kg as single IM dose. Max: 1 g. Meningitis Initially 100 mg/kg/day. Max: 4 g/day. Duration: 7-14 days. Treatment of serious miscellaneous infection other than meningitis 50-75 mg/kg/day. Max: 2 g/day.

Renal Dose

Administration

Contra Indications

Hypersensitivity to cephalosporins. History of hypersensitivity to penicillins.

Precautions

Avoid in patients w/ history of anaphylactic hypersensitivity reaction to penicillins. Monitor during therapy for potential super- or suprainfection. Pregnancy & lactation.

Pregnancy-Lactation

Interactions

May increase effects of anticoagulants. Potential disulfiram-like reaction w/ alcohol.

Adverse Effects

Side effects of Ceftriaxone + Sulbactam : GI effects including dose-related nausea, vomiting, diarrhea, abdominal cramps & flatulence. Dry mouth, bad taste, glossitis, furry tongue, anorexia, rectal bleeding & vaginitis.

Mechanism of Action

Ceftriaxone is a 3rd-generation cephalosporin antibiotic with a broad-spectrum activity which includes gram-positive and gram-negative aerobic and anaerobic bacteria. Ceftriaxone has a high degree of stability in the presence of beta-lactamase, both penicillinases and cephalosporinase of gram-positive and gram-negative bacteria. The bactericidal activity of ceftriaxone sodium results from inhibition of cell wall synthesis. Sulbactam is a potent, highly specific inhibitor of a wide variety of beta-lactamase produced by common gram-negative and gram-positive aerobes and anaerobes. By forming a protein complex with beta-lactamase, sulbactam irreversibly blocks their destructive hydrolytic activity. Thus, the full potential of ceftriaxone against Enterobacter and Pseudomonas species is restored by the addition of sulbactam. The combination of sulbactam and ceftriaxone sodium is active against all the organisms sensitive to ceftriaxone. In addition, it demonstrates synergistic activity [reduction in minimum inhibitory concentrations (MICs) for the combination versus those of each component] in a variety of organisms.

Note

Keftragard 1000mg + 500mg Injection manufactured by Ipca Laboratories Ltd.. Its generic name is Ceftriaxone + Sulbactam. Keftragard is availble in Nepal. Farmaco Nepal drug index information on Keftragard Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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