Kemadrin Tablet
Procyclidine Hydrochloride
2.5mg
Glaxo SmithKline Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 3.22 NPR |
Available as:
Indications
Kemadrin Tablet is used for:
Parkinsonism, Drug-induced extrapyramidal syndrome
Adult Dose
Oral
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3-4 divided doses. Up to 60 mg daily may be required in some cases.
Parenteral
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: Emergency cases: IV admin: 5-10 mg, higher doses may be needed; IM admin: 5-10 mg as a single dose, may repeat after 20 minutes if needed, to a max of 20 mg daily.
Elderly: Lower doses are required.
Child Dose
Oral
Dystonia in children
Child: 7-12 yr: 1.25 mg tid;
12-18 yr: 2.5 mg tid.
For emergency cases, a single dose may be given via IM or IV inj:
<2 yr: 0.5-2 mg;
2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg.
Renal Dose
Administration
Contra Indications
Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis.
Precautions
Patient w/ mental disorders, CV disease (e.g. tachycardia, cardiac arrhythmias, hypertention, hypotension). Hepatic and renal impairment. Avoid abrupt withdrawal. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause blurred vision, dizziness, confusion or disorientation, if affected, do not drive or operate machinery. Monitoring Parameters Monitor symptoms of extrapyramydal syndrome or Parkinson's disease, pulse, anticholinergic effects (e.g. CNS, bowel and bladder function).
Pregnancy-Lactation
Interactions
Increased plasma concentrations w/ paroxetine. Enhanced anticholinergic action w/ MAOIs and other anticholinergic drugs. Reduced therapeutic effect w/ cholinergic drugs. May antagonise the effect of parasympathomimetic agents. May reduce the absorption and therapeutic effect of sublingual or buccal nitrate tab. May reduce the efficacy of levodopa. May antagonise the GI effects of cisapride, domperidone and metoclopramide. May potentiate the vagolytic effects of quinidine. May reduce the absorption of ketoconazole.
Adverse Effects
Side effects of Procyclidine Hydrochloride :
Dry mouth, mydriasis, blurred vision, lightheadedness, giddiness, disorientation, GI effects (e.g. nausea, vomiting, epigastric distress, constipation), allergic reaction (e.g. rash), muscular weakness; vertigo, confusion, hallucinations at high doses; tremor, acute suppurative parotitis.
Mechanism of Action
Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic effect on smooth muscle.
Note
Kemadrin 2.5mg Tablet manufactured by Glaxo SmithKline Pharmaceuticals Ltd.. Its generic name is Procyclidine Hydrochloride. Kemadrin is availble in Nepal.
Farmaco Nepal drug index information on Kemadrin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.