Kofarest Drop
Ambroxol
7.5mg
Centaur Pharmaceuticals Pvt. Ltd.
| Pack size | 15ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 24.20 NPR |
Indications
Kofarest Drop is used for:
Mucolytic, Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, laryngitis, Pharyngitis, sinusitis and rhinitis associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis, Chronic pneumonia.
Adult Dose
Syrup: Adults -10 ml (2 teaspoonful), 3 times a day.
SR Capsule : Adults - 1 capsule, once daily
Child Dose
Paediatric Drops :
0 - 6 months old - 0.5 ml, 2 times a day,
6 - 12 months old - 1 ml, 2 times a day,
1 - 2 years old -1.25 ml, 2 times a day.
Syrup : 2 -5 years old - 2.5 ml (1/2 teaspoonful), 2-3 times a day,
5 - 10 years old - 5 ml (1 teaspoonful), 2-3 times a day,
10 years old - 10 ml (2 teaspoonful), 3 times a day.
SR Capsule : Children over 12 years old - 1 capsule, once daily
Renal Dose
Administration
Can be taken with or without food.
Contra Indications
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.
Precautions
Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Pregnancy-Lactation
Interactions
No clinically relevant unfavourable interaction with other medications has been reported.
Adverse Effects
Side effects of Ambroxol :
Tablet: Gastrointestinal Disorders: Dyspepsia, nausea, vomiting, diarrhoea and abdominal pain.
Immune System, Skin and Subcutaneous Tissue Disorders: Anaphylactic reactions including anaphylactic shock, angioedema, rash, urticaria, pruritus and other hypersensitivity.
Syrup: Gastrointestinal, Respiratory, Mediastinal and Thoracic Disorders: Dyspepsia, nausea, vomiting, diarrhoea and abdominal pain; oral and pharyngeal hypoaesthesia; dry mouth and throat.
Nervous System Disorders: Dysgeusia (eg, changed taste).
Immune System, Skin and Subcutaneous Tissue Disorders: Anaphylactic reactions including anaphylactic shock, angioedema, rash, urticaria, pruritus and other hypersensitivity.
Mechanism of Action
Ambroxol is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Ambroxol stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Ambroxol stimulates production of phospholipids of surfactant by alveolar cells. Ambroxol has anti-inflammatory properties. In patients with COPD, it improves airway patency.
Note
Kofarest 7.5mg Drop manufactured by Centaur Pharmaceuticals Pvt. Ltd.. Its generic name is Ambroxol. Kofarest is availble in Nepal.
Farmaco Nepal drug index information on Kofarest Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.