Larover Tablet

Chloroquine Phosphate
250mg
Aglowmed Pharmaceuticals Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price

Indications

Larover Tablet is used for: Rheumatoid arthritis, Malaria, Systemic lupus erythematosus, SLE, Amoebiasis

Adult Dose

Malaria Prevention: 500 mg (300 mg base) PO once/week Non-chloroquine-resistant 1 g (600 mg base) PO, THEN 500 mg (300 mg base) PO 6-8 hours later, THEN 500 mg (300 mg base) PO at 24 hours & 48 hours after initial dose Amebiasis, Extraintestinal 1 g (600 mg base) PO qDay for 2 days, THEN 500 mg (300 mg base) qDay for 14-21 days

Child Dose

Malaria Prophylaxis: 5 mg/kg PO q1Week Treatment 1st dose: 10 mg/kg PO x1 dose 6 hours after 1st dose: 5 mg/kg PO qDay x2 days

Renal Dose

Renal impairment: May need to reduce dose in prolonged treatment.

Administration

Should be taken with food.

Contra Indications

Hypersensitivity, known or suspected resistant P. falciparum infection, porphyria, retinal damage, concurrent hepatotoxic drugs.

Precautions

Psoriasis, diseases of the haematopoietic or CNS systems, myasthenia gravis, hepatic or renal impairment, G6PD deficiency, epilepsy, childn. Pregnancy and lactation. Slow infusion is used upon IV admin to prevent cardiotoxicity. Lactation: enters breast milk/not recommended

Pregnancy-Lactation

Interactions

Concomitant therapy with phenylbutazone predisposes to dermatitis, antagonises effect of neostigmine and pyridostigmine, reduces bioavailability of ampicillin. Cimetidine inhibits metabolism of chloroquine raising plasma levels. Potentially Fatal: Increased risks of inducing ventricular arrhythmias with halofantrine or other arrhythmogenic drugs eg, amiodarone. Increased risk of convulsions with mefloquine. Antacids reduce absorption of chloroquine hence admin should be separated by 4 hrs. Rarely Stevens-Johnson syndrome, when administered with pyrimethamine/sulphadoxine. Increased toxicity with quinacrine

Adverse Effects

Side effects of Chloroquine Phosphate : Retinopathy, hair loss, photosensitivity, tinnitus, myopathy (long-term therapy). Diarrhea, Loss of appetite, Nausea, Stomach cramps, Vomiting, Psychosis, seizures, leucopenia and rarely aplastic anaemia, hepatitis, GI upsets, dizziness, hypokalaemia, headache, pruritus, urticaria, difficulty in visual accommodation. Potentially Fatal: Cardiac and respiratory arrest, CV collapse, convulsions, coma.

Mechanism of Action

Chloroquine is used for malarial prophylaxis (as a suppressive) and in managing acute attacks of malaria. It is highly active against erythrocytic forms of P. vivax, P. malariae and P. falciparum. It influences Hb digestion by increasing intravesicular pH in malaria parasite cells and interferes with the nucleoprotein synthesis of the patient. It is also effective in extra intestinal amoebiasis. In RA chloroquine and more effectively hydroxychloroquine have a disease-modifying effect.

Note

Larover 250mg Tablet manufactured by Aglowmed Pharmaceuticals Ltd.. Its generic name is Chloroquine Phosphate. Larover is availble in Nepal. Farmaco Nepal drug index information on Larover Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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