Leptos Capsule
Sibutramine Hydrochloride
10mg
Acme Laboratories Ltd
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| Retail Price | 35.50 NPR |
Indications
Leptos Capsule is used for:
Obesity
Adult Dose
The recommended starting dose of (sibutramine hydrochloride monohydrate) is 10 mg administered once daily with or without food.
If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily.
The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Blood pressure and heart rate changes should be taken into account when making decisions regarding dose titration.
Doses above 15 mg daily are not recommended.
Child Dose
Renal Dose
Administration
Contra Indications
With a history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA)) (see WARNINGS).
with inadequately controlled hypertension > 145/90 mm Hg (see WARNINGS).
over 65 years of age.
receiving monoamine oxidase inhibitors (MAOIs) (see WARNINGS).
with hypersensitivity to sibutramine or any of the inactive ingredients of MERIDIA (sibutramine hydrochloride monohydrate) .
who have a major eating disorder (anorexia nervosa or bulimia nervosa).
taking other centrally acting weight loss drugs.
Precautions
Pulmonary Hypertension
Seizures
Bleeding
Gallstones
Renal Impairment
Hepatic Dysfunction
Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenicity
Impairment of Fertility
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Sibutramine Hydrochloride :
The most common events were dry mouth, anorexia, insomnia, constipation and headache.
Mechanism of Action
Sibutramine produces its therapeutic effects by inhibition of norepinephrine (NE), serotonin (5-hydroxytryptamine, 5-HT), and to a lesser extent, dopamine reuptake at the neuronal synapse. By inhibiting the reuptake of these neurotransmitters, sibutramine promotes a sense of satiety and decrease in appetite, thereby reducing food intake.
Note
Leptos 10mg Capsule manufactured by Acme Laboratories Ltd. Its generic name is Sibutramine Hydrochloride. Leptos is availble in Nepal.
Farmaco Nepal drug index information on Leptos Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.