Lledercort Tablet
Triamcinolone Acetonide
10mg
Wyeth
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Indications
Lledercort Tablet is used for:
Allergic and inflammatory responses, Inflammatory joint disease, Inflammatory skin conditions
Adult Dose
Intramuscular
Suppression of allergic and inflammatory disorders
Adult: As acetonide: 20-80 mg via deep IM into gluteal muscles.
Symptomatic control for hay fever
Adult: As acetonide: 40-100 mg via deep IM into gluteal muscles.
Rheumatic or arthritic disorders
Adult: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN
Intra-articular
Inflammatory joint diseases
Adult: As acetonide: Smaller joints: 2.5-5 mg (up to 10 mg), larger joints: 5-15 mg (up to 40 mg).
Max: 20-80 mg/treatment.
Intradermal
Inflammatory skin conditions
Adult: As acetonide: 1-3 mg/site. Max: 30 mg in total if several sites of inj used. Max: 12.5 mg/inj site. Max: 25 mg/lesion.
Child Dose
Intramuscular
Suppression of allergic and inflammatory disorders
Child: As acetonide: deep IM into gluteal muscle: initial 0.11 to 1.6 mg/kg/day in 3-4 divided doses.
Do not use in premature infants and infants of low birth weight as it contains benzyl alcohol.
Child: 6-12 years: 0.03-0.2 mg/kg IM every 1-7 days
>12 years: 60 mg IM every 6 weeks; may be supplemented by additional 20-100 mg IM PRN
>12 years, intralesional injection (10 mg/mL suspension): 1 mg per injection site 1 or more times weekly; not to exceed 30 mg/day
Symptomatic control for hay fever
Child: As acetonide: deep IM into gluteal muscle: initial 0.11 to 1.6 mg/kg/day in 3-4 divided doses.
Do not use in premature infants and infants of low birth weight as it contains benzyl alcohol.
Renal Dose
Administration
Dilute with local anesthetic (1% or 2% lidocaine without parabens) before intra-articular or intralesional injection
Dilute with D5/NS or D10/NS or NS or SWI before intralesional injection
Contra Indications
Triamcinolone Acetonide is contraindicated in patients with a sensitivity to the active or inactive ingredients. Untreated systemic fungal, bacterial, viral or parasitic infection, hypersensitivity. Neonates (Parenteral)
Precautions
Diabetes; hypertension, renal and liver impairment; glaucoma; psychosis; delayed tissue healing; cirrhosis; heart failure; recent MI; hypothyroidism; osteoporosis; peptic ulceration; thromboembolic disorders. Monitor height in children on prolonged therapy. Avoid rapid drug withdrawal. Elderly, children, pregnancy, lactation.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Lowering of plasma salicylates levels. Increased risk of GI bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of hyperkalaemia with amphotericin B, beta agonists, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin. Infections may develop if given with live vaccines.
Adverse Effects
Side effects of Triamcinolone Acetonide :
HPA axis supression, intracranial hypertension, Cushing's syndrome, growth retardation in children; osteoporosis, fractures. Peptic ulceration; glaucoma; hyperglycaemia; GI upsets; increased appetite; increased fragility of skin; behavioural changes.
Potentially Fatal: Acute adrenal insufficiency may be precipitated by infection or trauma in patients on long-term corticosteroid therapy or rapid withdrawal.
Mechanism of Action
Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.
Note
Lledercort 10mg Tablet manufactured by Wyeth. Its generic name is Triamcinolone Acetonide. Lledercort is availble in Nepal.
Farmaco Nepal drug index information on Lledercort Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.